A Mathematical Model of Skeletal Muscle Disease and Immune Response in the mdx Mouse

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dc.contributor.authorJarrah, Abdul Salamen
dc.contributor.authorCastiglione, Filippoen
dc.contributor.authorEvans, Nicholas P.en
dc.contributor.authorGrange, Robert W.en
dc.contributor.authorLaubenbacher, Reinhard C.en
dc.contributor.departmentHuman Nutrition, Foods, and Exerciseen
dc.contributor.departmentPopulation Health Sciencesen
dc.date.accessioned2017-09-18T09:41:43Zen
dc.date.available2017-09-18T09:41:43Zen
dc.date.issued2014-06-11en
dc.date.updated2017-09-18T09:41:43Zen
dc.description.abstractDuchenne muscular dystrophy (DMD) is a genetic disease that results in the death of affected boys by early adulthood. The genetic defect responsible for DMD has been known for over 25 years, yet at present there is neither cure nor effective treatment for DMD. During early disease onset, the mdx mouse has been validated as an animal model for DMD and use of this model has led to valuable but incomplete insights into the disease process. For example, immune cells are thought to be responsible for a significant portion of muscle cell death in the mdx mouse; however, the role and time course of the immune response in the dystrophic process have not been well described. In this paper we constructed a simple mathematical model to investigate the role of the immune response in muscle degeneration and subsequent regeneration in the mdx mouse model of Duchenne muscular dystrophy. Our model suggests that the immune response contributes substantially to the muscle degeneration and regeneration processes. Furthermore, the analysis of the model predicts that the immune system response oscillates throughout the life of the mice, and the damaged fibers are never completely cleared.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationAbdul Salam Jarrah, Filippo Castiglione, Nicholas P. Evans, Robert W. Grange, and Reinhard Laubenbacher, “A Mathematical Model of Skeletal Muscle Disease and Immune Response in the mdx Mouse,” BioMed Research International, vol. 2014, Article ID 871810, 11 pages, 2014. doi:10.1155/2014/871810en
dc.identifier.doihttps://doi.org/10.1155/2014/871810en
dc.identifier.urihttp://hdl.handle.net/10919/78960en
dc.language.isoenen
dc.publisherHindawien
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.holderCopyright © 2014 Abdul Salam Jarrah et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleA Mathematical Model of Skeletal Muscle Disease and Immune Response in the mdx Mouseen
dc.title.serialBioMed Research Internationalen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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