New tangles in the auxin signaling web.

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dc.contributor.authorWright, R. Clayen
dc.contributor.authorNemhauser, Jennifer L.en
dc.contributor.departmentBiological Systems Engineeringen
dc.date.accessioned2019-01-21T17:13:56Zen
dc.date.available2019-01-21T17:13:56Zen
dc.date.issued2015-01en
dc.date.updated2019-01-21T17:13:52Zen
dc.description.abstractPlants use auxin to relay critical information that shapes their growth and development. Auxin perception and transcriptional activation are mediated by the degradation of Aux/IAA repressor proteins. Degradation of Aux/IAAs relieves repression on Auxin Response Factors (ARFs), which bind DNA sequences called Auxin Response Elements (AuxREs). In most higher plant genomes, multiple paralogs exist for each part of the auxin nuclear signaling pathway. This potential combinatorial diversity in signaling pathways likely contributes to the myriad of context-specific responses to auxin. Recent structures of several domains from ARF proteins have exposed new modes of ARF dimerization, new models for ARF-AuxRE specificity, and the strong likelihood of larger order complexes formed by ARF and Aux/IAA homo- and heteromultimerization. Preliminary experiments support a role for these novel interactions in planta, further increasing the potential architectural complexity of this seemingly simple pathway.en
dc.description.versionPublished versionen
dc.format.extentPages 19en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.12703/P7-19en
dc.identifier.eissn2051-7599en
dc.identifier.issn2051-7599en
dc.identifier.orcidWright, Robert [0000-0001-7125-3943]en
dc.identifier.otherPMC4335792en
dc.identifier.other19 (PII)en
dc.identifier.pmid25750737en
dc.identifier.urihttp://hdl.handle.net/10919/86811en
dc.identifier.volume7en
dc.language.isoenen
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/25750737en
dc.rightsCreative Commons Attribution-NonCommercial 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.titleNew tangles in the auxin signaling web.en
dc.title.serialF1000prime reportsen
dc.typeArticle - Refereeden
dc.typeBook reviewen
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciencesen
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Biological Systems Engineeringen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/CALS T&R Facultyen

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