Clinicopathologic Significance of Histologic Grade, Pgp, and P53 Expression in Canine Lymphoma

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dc.contributor.authorDhaliwal, Ravinder S.en
dc.contributor.authorKitchell, Barbara E.en
dc.contributor.authorEhrhart, E. J.en
dc.contributor.authorValli, Victor E.en
dc.contributor.authorDervisis, Nikolaos G.en
dc.date.accessioned2016-11-15T20:48:05Zen
dc.date.available2016-11-15T20:48:05Zen
dc.date.issued2013-05-01en
dc.description.abstractTo characterize the expression of P-glycoprotein (Pgp) and p53 in different histologic grades of canine multicentric lymphosarcoma (LSA), 31 cases of LSA without prior treatment were studied. The expression levels of the Pgp and p53 proteins were evaluated for their clinicopathologic significance among standard histologic evaluation. Immunohistochemistry (IHC) was performed on formalin-fixed, paraffin-embedded archival samples of 31 previously untreated LSA cases to detect the expression of Pgp and p53. All dogs were subsequently treated with a combination chemotherapy protocol. Remission and survival durations were evaluated for correlation with histologic grade and presence of drug resistance markers. Of the 31 cases, 24 (80%) and 7 (22%) were positive for Pgp and p53, respectively. Overall, the median survival and duration of remission in the study was 246 days and 137 days, respectively. The National Cancer Institute working formulation histologic grade was not associated with either survival or duration of first remission (DOR). The Pgp protein expression and DOR and survival was not statistically significant. Expression of p53 was statistically correlated with survival.en
dc.description.versionPublished versionen
dc.format.extent175 - 184 (10) page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.5326/JAAHA-MS-5843en
dc.identifier.issn0587-2871en
dc.identifier.issue3en
dc.identifier.urihttp://hdl.handle.net/10919/73451en
dc.identifier.volume49en
dc.language.isoenen
dc.publisherAmerican Animal Hospital Associationen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000318556800004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectVeterinary Sciencesen
dc.subjectRESISTANCE-ASSOCIATED PROTEINen
dc.subjectP-GLYCOPROTEIN EXPRESSIONen
dc.subjectTUMOR-SUPPRESSOR GENEen
dc.subjectMULTIDRUG-RESISTANCEen
dc.subjectIMMUNOHISTOCHEMICAL DETECTIONen
dc.subjectMALIGNANT-LYMPHOMASen
dc.subjectDRUG-RESISTANCEen
dc.subjectOVARIAN-CANCERen
dc.subjectCELL-LINEen
dc.subjectDOGSen
dc.titleClinicopathologic Significance of Histologic Grade, Pgp, and P53 Expression in Canine Lymphomaen
dc.title.serialJournal of The American Animal Hospital Associationen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/CVM T&R Facultyen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Small Animal Clinical Sciencesen

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