The enantioselective synthesis of C₁₈-sphingosines

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dc.contributor.authorNugent, Thomas C.en
dc.contributor.committeechairHudlicky, Tomasen
dc.contributor.committeememberTanko, James M.en
dc.contributor.committeememberWhite, Robert H.en
dc.contributor.committeememberGibson, Harry W.en
dc.contributor.committeememberBrewer, Karen J.en
dc.contributor.departmentChemistryen
dc.date.accessioned2014-03-14T21:12:25Zen
dc.date.adate2008-06-06en
dc.date.available2014-03-14T21:12:25Zen
dc.date.issued1995en
dc.date.rdate2008-06-06en
dc.date.sdate2008-06-06en
dc.description.abstractBiocatalytic conversion of chlorobenzene to the corresponding homochiral cyclohexadiene cis-diol (113) allows, through careful symmetry-based planning, the stereodivergent synthesis of all sphingosine stereoisomers. This was achieved via the selective preparation of the appropriate diastereomer of azido alcohol (118), were C-4 and C-5 correspond to C-3 and C-2 of the sphingosine skeleton, respectively (Scheme 1).en
dc.description.degreePh. D.en
dc.format.extentvii, 155 leavesen
dc.format.mediumBTDen
dc.format.mimetypeapplication/pdfen
dc.identifier.otheretd-06062008-152643en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-06062008-152643/en
dc.identifier.urihttp://hdl.handle.net/10919/38065en
dc.language.isoenen
dc.publisherVirginia Techen
dc.relation.haspartLD5655.V856_1995.N844.pdfen
dc.relation.isformatofOCLC# 34050575en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subject.lccLD5655.V856 1995.N844en
dc.titleThe enantioselective synthesis of C₁₈-sphingosinesen
dc.typeDissertationen
dc.type.dcmitypeTexten
thesis.degree.disciplineChemistryen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.leveldoctoralen
thesis.degree.namePh. D.en

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