Harnessing Tissue Engineering Tools to Interrogate Host-Microbiota Crosstalk in Cancer

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dc.contributor.authorUdayasuryan, Barathen
dc.contributor.authorNguyen, Tam T. D.en
dc.contributor.authorSlade, Daniel J.en
dc.contributor.authorVerbridge, Scott S.en
dc.contributor.departmentBiochemistryen
dc.contributor.departmentSchool of Biomedical Engineering and Sciencesen
dc.date.accessioned2021-08-31T14:42:27Zen
dc.date.available2021-08-31T14:42:27Zen
dc.date.issued2020-12-18en
dc.date.updated2021-08-31T14:42:22Zen
dc.description.abstractRecent studies have begun to highlight the diverse and tumor-specific microbiomes across multiple cancer types. We believe this work raises the important question of whether the classical “Hallmarks of Cancer” should be expanded to include tumor microbiomes. To answer this question, the causal relationships and co-evolution of these microbiotic tumor ecosystems must be better understood. Because host-microbe interactions should be studied in a physiologically relevant context, animal models have been preferred. Yet these models are often poor mimics of human tumors and are difficult to interrogate at high spatiotemporal resolution. We believe that in vitro tissue engineered platforms could provide a powerful alternative approach that combines the high-resolution of in vitro studies with a high degree of physiological relevance. This review will focus on tissue engineered approaches to study host-microbe interactions and to establish their role as an emerging hallmark of cancer with potential as a therapeutic target.en
dc.description.versionPublished versionen
dc.format.extent18 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifierARTN 101878 (Article number)en
dc.identifier.doihttps://doi.org/10.1016/j.isci.2020.101878en
dc.identifier.eissn2589-0042en
dc.identifier.issn2589-0042en
dc.identifier.issue12en
dc.identifier.orcidSlade, Daniel [0000-0001-5634-7220]en
dc.identifier.orcidVerbridge, Scott [0000-0002-4074-8799]en
dc.identifier.otherS2589-0042(20)31075-0 (PII)en
dc.identifier.pmid33344921en
dc.identifier.urihttp://hdl.handle.net/10919/104882en
dc.identifier.volume23en
dc.language.isoenen
dc.publisherCell Pressen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000600670000120&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectfusobacterium-nucleatumen
dc.subjecthelicobacter-pylorien
dc.subjectmodelsen
dc.subjectcocultureen
dc.subjectresponsesen
dc.subjectbacteriaen
dc.subjectplatformen
dc.subjectcellsen
dc.subjectbioengineeringen
dc.subjectcanceren
dc.subjectmicrobiomeen
dc.subjecttissue engineeringen
dc.titleHarnessing Tissue Engineering Tools to Interrogate Host-Microbiota Crosstalk in Canceren
dc.title.serialiScienceen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherJournalen
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciencesen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Biochemistryen
pubs.organisational-group/Virginia Tech/Engineeringen
pubs.organisational-group/Virginia Tech/University Research Institutesen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciencesen
pubs.organisational-group/Virginia Tech/Engineering/Biomedical Engineering and Mechanicsen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Engineering/COE T&R Facultyen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/CALS T&R Facultyen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciences/Durelle Scotten

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