The role of the apparent rate constant of cross-bridge transition from the strong binding state (G app ) in skeletal muscle force production

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dc.contributor.authorWard, Christopher W.en
dc.contributor.committeecochairLee, John C.en
dc.contributor.committeecochairWilliams, Jay H.en
dc.contributor.committeememberEng, Ludeman A.en
dc.contributor.committeememberKlug, Gary A.en
dc.contributor.committeememberMcGrath, Charles J.en
dc.contributor.departmentVeterinary Medical Sciencesen
dc.date.accessioned2014-03-14T21:12:02Zen
dc.date.adate2008-06-06en
dc.date.available2014-03-14T21:12:02Zen
dc.date.issued1996en
dc.date.rdate2008-06-06en
dc.date.sdate2008-06-06en
dc.description.abstractForce regulation at the level of the actin-myosin cross-bridge (XB) can be described by a 2 state model in which the XB's cycle between a strongly bound (SB), force generating state and a weakly bound (WB), non-force generating state. This cycle can be characterized by the apparent rate constants for transition into the SB state (fapp) and returning to the WB state (gapp), Increases in XB force can be accounted for by an increase in fapp a decrease in gapp., or both. While effort towards understanding XB force regulation has focused on the notion that force production is primarily regulated by fapp the purpose of this investigation was to determine if gapp continues to force regulation at the XB and to determine whether gapp differs in,muscles with differing contractile characteristics.en
dc.description.degreePh. D.en
dc.format.extentxi, 98 leavesen
dc.format.mediumBTDen
dc.format.mimetypeapplication/pdfen
dc.identifier.otheretd-06062008-151126en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-06062008-151126/en
dc.identifier.urihttp://hdl.handle.net/10919/37983en
dc.language.isoenen
dc.publisherVirginia Techen
dc.relation.haspartLD5655.V856_1996.W373.pdfen
dc.relation.isformatofOCLC# 35894433en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectcross-bridgesen
dc.subjectcalciumen
dc.subjectcontractionen
dc.subjectmuscleen
dc.subjectmyosinen
dc.subject.lccLD5655.V856 1996.W373en
dc.titleThe role of the apparent rate constant of cross-bridge transition from the strong binding state (G app ) in skeletal muscle force productionen
dc.typeDissertationen
dc.type.dcmitypeTexten
thesis.degree.disciplineVeterinary Medical Sciencesen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.leveldoctoralen
thesis.degree.namePh. D.en

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