Stochastic Boolean model of normal and aberrant cell cycles in budding yeast

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dc.contributor.authorTaoma, Kittisaken
dc.contributor.authorTyson, John J.en
dc.contributor.authorLaomettachit, Teeraphanen
dc.contributor.authorKraikivski, Pavelen
dc.date.accessioned2025-01-02T18:53:44Zen
dc.date.available2025-01-02T18:53:44Zen
dc.date.issued2024-10-18en
dc.description.abstractThe cell cycle of budding yeast is governed by an intricate protein regulatory network whose dysregulation can lead to lethal mistakes or aberrant cell division cycles. In this work, we model this network in a Boolean framework for stochastic simulations. Our model is sufficiently detailed to account for the phenotypes of 40 mutant yeast strains (83% of the experimentally characterized strains that we simulated) and also to simulate an endoreplicating strain (multiple rounds of DNA synthesis without mitosis) and a strain that exhibits ‘Cdc14 endocycles’ (periodic transitions between metaphase and anaphase). Because our model successfully replicates the observed properties of both wild-type yeast cells and many mutant strains, it provides a reasonable, validated starting point for more comprehensive stochastic-Boolean models of cell cycle controls. Such models may provide a better understanding of cell cycle anomalies in budding yeast and ultimately in mammalian cells.en
dc.description.versionPublished versionen
dc.format.extent12 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifierARTN 121 (Article number)en
dc.identifier.doihttps://doi.org/10.1038/s41540-024-00452-3en
dc.identifier.eissn2056-7189en
dc.identifier.issn2056-7189en
dc.identifier.issue1en
dc.identifier.orcidKraikivski, Pavel [0000-0001-7742-0140]en
dc.identifier.other10.1038/s41540-024-00452-3 (PII)en
dc.identifier.pmid39420008en
dc.identifier.urihttps://hdl.handle.net/10919/123873en
dc.identifier.volume10en
dc.language.isoenen
dc.publisherNature Portfolioen
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/39420008en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subject.meshSaccharomycetalesen
dc.subject.meshSaccharomyces cerevisiaeen
dc.subject.meshCell Cycle Proteinsen
dc.subject.meshSaccharomyces cerevisiae Proteinsen
dc.subject.meshStochastic Processesen
dc.subject.meshCell Cycleen
dc.subject.meshDNA Replicationen
dc.subject.meshMutationen
dc.subject.meshModels, Biologicalen
dc.subject.meshComputer Simulationen
dc.titleStochastic Boolean model of normal and aberrant cell cycles in budding yeasten
dc.title.serialNPJ Systems Biology and Applicationsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherArticleen
dc.type.otherJournalen
dcterms.dateAccepted2024-10-06en
pubs.organisational-groupVirginia Techen
pubs.organisational-groupVirginia Tech/Scienceen
pubs.organisational-groupVirginia Tech/Science/Dean of Scienceen

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