Dopamine and serotonin in human substantia nigra track social context and value signals during economic exchange

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dc.contributor.authorBatten, Seth R.en
dc.contributor.authorBang, Danen
dc.contributor.authorKopell, Brian H.en
dc.contributor.authorDavis, Arianna N.en
dc.contributor.authorHeflin, Matthewen
dc.contributor.authorFu, Qixiuen
dc.contributor.authorPerl, Oferen
dc.contributor.authorZiafa, Kimiaen
dc.contributor.authorHashemi, Aliceen
dc.contributor.authorSaez, Ignacioen
dc.contributor.authorBarbosa, Leonardo S.en
dc.contributor.authorTwomey, Thomasen
dc.contributor.authorLohrenz, Terryen
dc.contributor.authorWhite, Jason P.en
dc.contributor.authorDayan, Peteren
dc.contributor.authorCharney, Alexander W.en
dc.contributor.authorFigee, Martijnen
dc.contributor.authorMayberg, Helen S.en
dc.contributor.authorKishida, Kenneth T.en
dc.contributor.authorGu, Xiaosien
dc.contributor.authorMontague, P. Readen
dc.date.accessioned2024-02-27T15:27:48Zen
dc.date.available2024-02-27T15:27:48Zen
dc.date.issued2024-02-26en
dc.description.abstractDopamine and serotonin are hypothesized to guide social behaviours. In humans, however, we have not yet been able to study neuromodulator dynamics as social interaction unfolds. Here, we obtained subsecond estimates of dopamine and serotonin from human substantia nigra pars reticulata during the ultimatum game. Participants, who were patients with Parkinson’s disease undergoing awake brain surgery, had to accept or reject monetary offers of varying fairness from human and computer players. They rejected more offers in the human than the computer condition, an effect of social context associated with higher overall levels of dopamine but not serotonin. Regardless of the social context, relative changes in dopamine tracked trial-by-trial changes in offer value—akin to reward prediction errors—whereas serotonin tracked the current offer value. These results show that dopamine and serotonin fluctuations in one of the basal ganglia’s main output structures reflect distinct social context and value signals.en
dc.description.sponsorshipThis work was supported by the Lundbeck Foundation (D.B., grant no. R368-2021-325), Wellcome (D.B., grant no. 213630/Z/18/Z; P.R.M., grant no. 091188/Z/10/Z), the Swartz Foundation (P.R.M., grant no. 2019-11), NIH-NCATS (K.T.K., grant no. KL2TR001421), NIH-NIDA (K.T.K., grant no. R01-DA048096), NIH-NINDS (K.T.K. and P.R.M., grant no. R01-NS092701), NIH-NIMH (K.T.K., grant no. R01-MH121099; X.G., grant nos. R21-MH120789, R01-MH122611 and R01-MH123069; K.T.K., X.G. and P.R.M., grant no. R01-MH124115; P.R.M., grant nos. R01-MH122512 and R01-MH122948), a Virginia Tech Foundation Seale Innovation Award (P.R.M., grant no. FY22), seed funding from the Icahn School of Medicine at Mount Sinai (X.G.), the Max Planck Society (P.D.) and the Humboldt Foundation (P.D.). The Wellcome Centre for Human Neuroimaging is supported by core funding from Wellcome (grant no. 203147/Z/16/Z).en
dc.identifier.doihttps://doi.org/10.1038/s41562-024-01831-wen
dc.identifier.urihttps://hdl.handle.net/10919/118196en
dc.language.isoen_USen
dc.publisherNature Researchen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleDopamine and serotonin in human substantia nigra track social context and value signals during economic exchangeen
dc.title.serialNature Human Behavioren
dc.typeArticle - Refereeden

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