Dynamics of Adaptive Alleles in Divergently Selected Body Weight Lines of Chickens

Simple item page
dc.contributor.authorPettersson, Mats E.en
dc.contributor.authorJohansson, Anna M.en
dc.contributor.authorSiegel, Paul B.en
dc.contributor.authorCarlborg, Örjanen
dc.contributor.departmentAnimal and Poultry Sciencesen
dc.date.accessioned2019-12-23T17:29:15Zen
dc.date.available2019-12-23T17:29:15Zen
dc.date.issued2013-12en
dc.description.abstractBy studying genomic changes over time in populations subjected to strong artificial directional selection, we can gain insights to the dynamics of beneficial alleles originating from the founder population or emerging as novel mutations undergoing ongoing selection. The Virginia lines are a chicken resource population generated by long-term bi-directional, single-trait selection for juvenile body weight. We studied genome-wide allele frequency changes from generation 40 to 53 using genome-wide genotypes from directional and relaxed selection lines. Overall, there were small changes in allele frequencies at individual loci over the studied time period; but, on average, the changes were greater in lines with larger phenotypic changes. This is consistent with previous findings that much of the response to selection over the first 40 years of selection was attributable to utilization of standing genetic variation at many loci in the genome, indicating a mostly polygenic architecture for body weight. Over the course of the selection experiment, the largest phenotypic response to selection was observed in the high-weight selected line, and in this line we detected a single locus where the allele frequency changed rapidly during a late stage of the experiment. This locus likely contains a novel, beneficial mutation that appeared between generations 40 and 45 and was driven to fixation in 5 to 10 generations. This result illustrates the dependence of continued long-term selection response on standing genetic variation at many loci as well as strong, novel, beneficial mutations.en
dc.description.notesThis study was funded by the Swedish Foundation for Strategic Research, by the Swedish Research Council for Environment, Agricultural Sciences, and Spatial Planning (FORMAS), and by a EURYI Award (to O.C.).en
dc.description.sponsorshipSwedish Foundation for Strategic ResearchSwedish Foundation for Strategic Research; Swedish Research Council for Environment, Agricultural Sciences, and Spatial Planning (FORMAS)Swedish Research Council Formas; EURYIEuropean Science Foundation (ESF)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1534/g3.113.008375en
dc.identifier.eissn2160-1836en
dc.identifier.issue12en
dc.identifier.pmid24170737en
dc.identifier.urihttp://hdl.handle.net/10919/96206en
dc.identifier.volume3en
dc.language.isoenen
dc.publisherGenetics Society of Americaen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectdivergent selectionen
dc.subjectbody weighten
dc.subjectchickenen
dc.subjectartificial selectionen
dc.subjectselective sweepsen
dc.titleDynamics of Adaptive Alleles in Divergently Selected Body Weight Lines of Chickensen
dc.title.serialG3-Genes Genomes Geneticsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
2305.full.pdf
Size:
1.54 MB
Format:
Adobe Portable Document Format
Description:
Download

Collections

Scholarly Works, School of Animal Sciences