A cell–ECM mechanism for connecting the ipsilateral eye to the brain

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dc.contributor.authorSu, Jianminen
dc.contributor.authorSabbagh, Ubadahen
dc.contributor.authorLiang, Yanpingen
dc.contributor.authorOlejníková, Lucieen
dc.contributor.authorDixon, Karen G.en
dc.contributor.authorRussell, Ashley L.en
dc.contributor.authorChen, Jiangen
dc.contributor.authorPan, Yuchin Alberten
dc.contributor.authorTriplett, Jason W.en
dc.contributor.authorFox, Michael A.en
dc.date.accessioned2021-10-20T14:15:22Zen
dc.date.available2021-10-20T14:15:22Zen
dc.date.issued2021-10-15en
dc.description.abstractInformation about features in the visual world is parsed by circuits in the retina and is then transmitted to the brain by distinct subtypes of retinal ganglion cells (RGCs). Axons from RGC subtypes are stratified in retinorecipient brain nuclei, such as the superior colliculus (SC), to provide a segregated relay of parallel and feature-specific visual streams. Here, we sought to identify the molecular mechanisms that direct the stereotyped laminar targeting of these axons. We focused on ipsilateral-projecting subtypes of RGCs (ipsiRGCs) whose axons target a deep SC sublamina. We identified an extracellular glycoprotein, Nephronectin (NPNT), whose expression is restricted to this ipsiRGC-targeted sublamina. SC-derived NPNT and integrin receptors expressed by ipsiRGCs are both required for the targeting of ipsiRGC axons to the deep sublamina of SC. Thus, a cell–extracellular matrix (ECM) recognition mechanism specifies precise laminar targeting of ipsiRGC axons and the assembly of eye-specific parallel visual pathways.en
dc.description.sponsorshipThis work was supported in part by the following grants from the NIH: EY021222 (M.A.F.), EY030568 (M.A.F.), NS105141 (M.A.F.), NS113459 (U.S.), EY025627 (J.W.T.), and EY029874 (J.W.T.).en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1073/pnas.2104343118en
dc.identifier.issue42en
dc.identifier.urihttp://hdl.handle.net/10919/105425en
dc.identifier.volume118en
dc.language.isoenen
dc.publisherNational Academy of Sciencesen
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectretinaen
dc.subjectaxon targetingen
dc.subjectdevelopmenten
dc.subjectextracellular matrixen
dc.subjectsuperior colliculusen
dc.titleA cell–ECM mechanism for connecting the ipsilateral eye to the brainen
dc.title.serialPNASen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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Scholarly Works, Fralin Biomedical Research Institute at VTC
Scholarly Works, Biological Sciences
Scholarly Works, Biomedical Sciences and Pathobiology
Scholarly Works, School of Neuroscience
Scholarly Works, Virginia Tech Carilion School of Medicine (VTCSOM)