A cell–ECM mechanism for connecting the ipsilateral eye to the brain
| dc.contributor.author | Su, Jianmin | en |
| dc.contributor.author | Sabbagh, Ubadah | en |
| dc.contributor.author | Liang, Yanping | en |
| dc.contributor.author | Olejníková, Lucie | en |
| dc.contributor.author | Dixon, Karen G. | en |
| dc.contributor.author | Russell, Ashley L. | en |
| dc.contributor.author | Chen, Jiang | en |
| dc.contributor.author | Pan, Yuchin Albert | en |
| dc.contributor.author | Triplett, Jason W. | en |
| dc.contributor.author | Fox, Michael A. | en |
| dc.date.accessioned | 2021-10-20T14:15:22Z | en |
| dc.date.available | 2021-10-20T14:15:22Z | en |
| dc.date.issued | 2021-10-15 | en |
| dc.description.abstract | Information about features in the visual world is parsed by circuits in the retina and is then transmitted to the brain by distinct subtypes of retinal ganglion cells (RGCs). Axons from RGC subtypes are stratified in retinorecipient brain nuclei, such as the superior colliculus (SC), to provide a segregated relay of parallel and feature-specific visual streams. Here, we sought to identify the molecular mechanisms that direct the stereotyped laminar targeting of these axons. We focused on ipsilateral-projecting subtypes of RGCs (ipsiRGCs) whose axons target a deep SC sublamina. We identified an extracellular glycoprotein, Nephronectin (NPNT), whose expression is restricted to this ipsiRGC-targeted sublamina. SC-derived NPNT and integrin receptors expressed by ipsiRGCs are both required for the targeting of ipsiRGC axons to the deep sublamina of SC. Thus, a cell–extracellular matrix (ECM) recognition mechanism specifies precise laminar targeting of ipsiRGC axons and the assembly of eye-specific parallel visual pathways. | en |
| dc.description.sponsorship | This work was supported in part by the following grants from the NIH: EY021222 (M.A.F.), EY030568 (M.A.F.), NS105141 (M.A.F.), NS113459 (U.S.), EY025627 (J.W.T.), and EY029874 (J.W.T.). | en |
| dc.description.version | Published version | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.doi | https://doi.org/10.1073/pnas.2104343118 | en |
| dc.identifier.issue | 42 | en |
| dc.identifier.uri | http://hdl.handle.net/10919/105425 | en |
| dc.identifier.volume | 118 | en |
| dc.language.iso | en | en |
| dc.publisher | National Academy of Sciences | en |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | en |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | en |
| dc.subject | retina | en |
| dc.subject | axon targeting | en |
| dc.subject | development | en |
| dc.subject | extracellular matrix | en |
| dc.subject | superior colliculus | en |
| dc.title | A cell–ECM mechanism for connecting the ipsilateral eye to the brain | en |
| dc.title.serial | PNAS | en |
| dc.type | Article - Refereed | en |
| dc.type.dcmitype | Text | en |