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dc.contributor.authorVanderwerker, Zachary Thomasen_US
dc.date.accessioned2013-12-09T09:00:08Z
dc.date.available2013-12-09T09:00:08Z
dc.date.issued2013-12-08en_US
dc.identifier.othervt_gsexam:1706en_US
dc.identifier.urihttp://hdl.handle.net/10919/24449
dc.description.abstractSince the rise of multicellular organisms, nature has created a wide range of solutions for life on Earth. This diverse set of solutions presents a broad design space for a number of bio-inspired technologies in many different fields. Of particular interest for this work is the computational and processing power of neurons in the brain. Neuronal networks for transmitting and processing signals have advantages to their electronic counterparts in terms of power efficiency and the ability to handle component failure. In this thesis, an artificial axon system using droplet on hydrogel bilayers (DHBs) in conjunction with alamethicin channels was developed to show properties of action potential signal propagation that occur in myelinated nerve cells. The research demonstrates that the artificial axon system is capable of modifying signals that travel perpendicular to a lipid bilayer interface due to the voltage-gating properties of alamethicin within the connected bilayer. The system was used to show a signal boosting behavior similar to what occurs in the nodes of Ranvier of a myelinated axon. In addition, the artificial axon system was used to show that alamethicin channels within a lipid bilayer behave similarly to slow-acting potassium channels in a real axon in that they follow a sigmoid activation curve in response to a step potential change.en_US
dc.format.mediumETDen_US
dc.publisherVirginia Techen_US
dc.rightsThis Item is protected by copyright and/or related rights. Some uses of this Item may be deemed fair and permitted by law even without permission from the rights holder(s), or the rights holder(s) may have licensed the work for use under certain conditions. For other uses you need to obtain permission from the rights holder(s).en_US
dc.subjectLipid bilayeren_US
dc.subjectdroplet interface bilayeren_US
dc.subjectdroplet on hydrogel bilayer (DHB)en_US
dc.subjectalamethicinen_US
dc.subjectartificial axon systemen_US
dc.titleUsing Lipid Bilayers in an Artificial Axon Systemen_US
dc.typeThesisen_US
dc.contributor.departmentMechanical Engineeringen_US
dc.description.degreeMaster of Scienceen_US
thesis.degree.nameMaster of Scienceen_US
thesis.degree.levelmastersen_US
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen_US
thesis.degree.disciplineMechanical Engineeringen_US
dc.contributor.committeechairKasarda, Mary E. F.en_US
dc.contributor.committeechairLeo, Donald J.en_US
dc.contributor.committeememberSarles, Stephen Andrewen_US


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