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dc.contributor.authorAdou, Ebaen_US
dc.date.accessioned2014-03-14T20:19:55Z
dc.date.available2014-03-14T20:19:55Z
dc.date.issued2005-11-28en_US
dc.identifier.otheretd-12072005-110557en_US
dc.identifier.urihttp://hdl.handle.net/10919/29973
dc.description.abstractISOLATION AND CHARACTERIZATION OF BIOACTIVE COMPOUNDS FROM SURINAME AND MADAGASCAR FLORA AND A SYNTHETIC APPROACH TO LUCILACTAENE ABSTRACT Eba Adou As part of an International Cooperative Biodiversity Group (ICBG), extracts of plants from Suriname and Madagascar were bioassayed for cytotoxicity and antimalarial activity. Six cytotoxic extracts and one potential antimalarial were selected for fractionation, and yielded a number of bioactive compounds which were characterized by spectroscopy methods. Craspidospermum verticillatum (Apocynaceae) yielded four known indole alkoids. Casimirella sp (Icacinaceae) gave three new and five known diterpenoids. Pentopetia androsaemifolia (Apocynaceae) afforded one new and three known cardenolide glycosides. Physalis angulata (Solanaceae) yielded seven known physalins. Roupellina boivinnii (Apocynaceae) yielded four known and three new cardenolide glycosides, and three known cucurbitacins were isolated from Octolepis aff. dioica (Thymelaeaceae). In addition to these structural studies, a synthetic approach to lucilactaene, a cell cycle inhibitor was developed.en_US
dc.publisherVirginia Techen_US
dc.relation.haspartAdouebaetdpdf22.pdfen_US
dc.rightsI hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Virginia Tech or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report.en_US
dc.subjectLucilactaeneen_US
dc.subjectAnticancer agentsen_US
dc.subjectCytotoxicity assayen_US
dc.subjectIndole alkaloidsen_US
dc.subjectp53 Tumor suppressor Geneen_US
dc.subjectPhysalinsen_US
dc.subjectCardenolide glycosidesen_US
dc.subjectDiterpenoidsen_US
dc.subjectCucurbitacinsen_US
dc.subjectCell cycleen_US
dc.subjectCell cycle inhibitoren_US
dc.titleI. ISOLATION AND CHARACTERIZATION OF BIOACTIVE COMPOUNDS FROM SURINAME AND MADAGASCAR FLORA. II. A SYNTHETIC APPROACH TO LUCILACTAENEen_US
dc.typeDissertationen_US
dc.contributor.departmentChemistryen_US
dc.description.degreePh. D.en_US
thesis.degree.namePh. D.en_US
thesis.degree.leveldoctoralen_US
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen_US
thesis.degree.disciplineChemistryen_US
dc.contributor.committeechairKingston, David G. I.en_US
dc.contributor.committeememberLong, Timothy E.en_US
dc.contributor.committeememberDeck, Paul A.en_US
dc.contributor.committeememberTanko, James M.en_US
dc.contributor.committeememberEtzkorn, Felicia A.en_US
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-12072005-110557/en_US
dc.date.sdate2005-12-07en_US
dc.date.rdate2006-01-30
dc.date.adate2006-01-30en_US


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