I. Isolation and Characterization of Bioactive Compounds From Suriname and Madagascar flora. II. A Synthetic Approach to Lucilactaene

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dc.contributor.authorAdou, Ebaen
dc.contributor.committeechairKingston, David G. I.en
dc.contributor.committeememberLong, Timothy E.en
dc.contributor.committeememberDeck, Paul A.en
dc.contributor.committeememberTanko, James M.en
dc.contributor.committeememberEtzkorn, Felicia A.en
dc.contributor.departmentChemistryen
dc.date.accessioned2014-03-14T20:19:55Zen
dc.date.adate2006-01-30en
dc.date.available2014-03-14T20:19:55Zen
dc.date.issued2005-11-28en
dc.date.rdate2006-01-30en
dc.date.sdate2005-12-07en
dc.description.abstractAs part of an International Cooperative Biodiversity Group (ICBG), extracts of plants from Suriname and Madagascar were bioassayed for cytotoxicity and antimalarial activity. Six cytotoxic extracts and one potential antimalarial were selected for fractionation, and yielded a number of bioactive compounds which were characterized by spectroscopy methods. Craspidospermum verticillatum (Apocynaceae) yielded four known indole alkoids. Casimirella sp (Icacinaceae) gave three new and five known diterpenoids. Pentopetia androsaemifolia (Apocynaceae) afforded one new and three known cardenolide glycosides. Physalis angulata (Solanaceae) yielded seven known physalins. Roupellina boivinnii (Apocynaceae) yielded four known and three new cardenolide glycosides, and three known cucurbitacins were isolated from Octolepis aff. dioica (Thymelaeaceae). In addition to these structural studies, a synthetic approach to lucilactaene, a cell cycle inhibitor was developed.en
dc.description.degreePh. D.en
dc.identifier.otheretd-12072005-110557en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-12072005-110557/en
dc.identifier.urihttp://hdl.handle.net/10919/29973en
dc.publisherVirginia Techen
dc.relation.haspartAdouebaetdpdf22.pdfen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectLucilactaeneen
dc.subjectAnticancer agentsen
dc.subjectCytotoxicity assayen
dc.subjectIndole alkaloidsen
dc.subjectp53 Tumor suppressor Geneen
dc.subjectPhysalinsen
dc.subjectCardenolide glycosidesen
dc.subjectDiterpenoidsen
dc.subjectCucurbitacinsen
dc.subjectCell cycleen
dc.subjectCell cycle inhibitoren
dc.titleI. Isolation and Characterization of Bioactive Compounds From Suriname and Madagascar flora. II. A Synthetic Approach to Lucilactaeneen
dc.typeDissertationen
thesis.degree.disciplineChemistryen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.leveldoctoralen
thesis.degree.namePh. D.en

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