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dc.contributor.authorPantaleon, Lucas Guillermoen_US
dc.date.accessioned2014-03-14T20:41:02Z
dc.date.available2014-03-14T20:41:02Z
dc.date.issued2005-06-30en_US
dc.identifier.otheretd-07042005-115445en_US
dc.identifier.urihttp://hdl.handle.net/10919/33885
dc.description.abstractJustification: Endotoxemia and sepsis are major causes of mortality in horses, resulting in significant economic losses for the equine industry. Objective: To determine the effects of the combination of Hypertonic Saline Solution and Hetastarch in endotoxemic horses. Animals: Eighteen horses divided into three groups of six. Procedure: All horses received a total dose of intravenous E. coli endotoxin infused at 50 ug/kg; divided into a bolus infusion of 20 ug/kg followed by 30 ug/kg given over 30 minutes. After induction of endotoxic shock; group I (control) received a bolus (15 ml/kg) of isotonic solution, group II (isotonic solution) received a bolus (60 ml/kg) of balanced polyionic crystalloid solution and group III (Hypertonic saline plus Hetastarch) received a bolus of 5 ml/kg of hypertonic saline, followed by a bolus of 10 ml/kg of Hetastarch. Hemodynamic and hematological parameters were measure at different time points. Results: Hemodynamic, biochemical and hematological differences were observed among the three groups. Conclusions and Relevance: the use of large volume crystalloid fluid resuscitation causes volume overload, exerting deleterious effects on the cardiovascular and pulmonary systems. The use of small volume resuscitation (HSS-HES) showed a trend towards better cardiovascular and pulmonary function, without the deleterious effects of volume overload. Abnormalities with regard to coagulation were not seen for the time period of the experimental protocol and the dose regimen used for HSS-HES. Small volume resuscitation in critically ill horses shows promise for its beneficial effects in cardiovascular and pulmonary functions.en_US
dc.publisherVirginia Techen_US
dc.relation.haspartfinalthesis.pdfen_US
dc.rightsI hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Virginia Tech or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report.en_US
dc.subjectHypertonic Salineen_US
dc.subjectHetastarchen_US
dc.subjecthorseen_US
dc.subjectendotoxemiaen_US
dc.titleCardiovascular and Hematological Effects of Hetastarch and Hypertonic Saline Solutions During Experimental Endotoxemia in Horsesen_US
dc.typeThesisen_US
dc.contributor.departmentVeterinary Medical Sciencesen_US
dc.description.degreeMaster of Scienceen_US
thesis.degree.nameMaster of Scienceen_US
thesis.degree.levelmastersen_US
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen_US
thesis.degree.disciplineVeterinary Medical Sciencesen_US
dc.contributor.committeechairFurr, Martin O.en_US
dc.contributor.committeememberSmith, Alisonen_US
dc.contributor.committeememberMcKenzie, Harold C. IIIen_US
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-07042005-115445/en_US
dc.date.sdate2005-07-04en_US
dc.date.rdate2012-10-01
dc.date.adate2005-07-21en_US


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