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dc.contributor.authorGyenai, Kwaku Barimaen_US
dc.date.accessioned2014-03-14T20:43:25Z
dc.date.available2014-03-14T20:43:25Z
dc.date.issued2005-07-22en_US
dc.identifier.otheretd-08142005-160658en_US
dc.identifier.urihttp://hdl.handle.net/10919/34529
dc.description.abstractDilated cardiomyopathy (DCM) or round heart disease is a muscle disease of the heart which is characterized by ventricular dilatation and abnormal systolic and diastolic left ventricular function. In animals, including turkeys and humans, DCM is the major cause of morbidity and mortality which results from heart failure. In the turkey, DCM can be idiopathic or induced. Since idiopathic or spontaneous DCM occurs in about 1-4% of normal turkeys, it is of significant concern to the poultry industry. In this study, it was proposed that the incidence and severity of DCM in the turkey may have a genetic basis. To test this hypothesis, I investigated differences in the incidence and severity of DCM in five domesticated turkey varieties including Blue Slate (BS), Bourbon Red (BR), Narragansett (N), Royal Palm (RP) and Spanish Black (SB). Preliminary investigations tested the reliability of echocardiography (ECHO) as a non-invasive and non-destructive technique for diagnosing DCM in a large number of birds from hatch to four weeks-of-age. One-day-old poults for both the preliminary and hypothesis testing investigations were obtained from Privett Hatcheries (Portales, New Mexico). The birds were raised under standard management conditions. In the preliminary investigation and to test my hypothesis, DCM was induced by feeding birds ad libitum standard diets containing 700 parts per million furazolidone. Results of the preliminary investigations showed that left ventricular end-diastolic dimension (LVEDD) and left ventricular end-systolic dimension (LVESD) were the most consistent ECHO indicators of DCM from hatch to 4 weeks-of-age. Variety differences in response to furazolidone were evaluated using these parameters as well as percent mortality. At 9 days-of-age, differences between control and treatment birds for percent mortality and LVESD were significant in the RP variety only but significant for LVEDD in RP and SB. At 29 and 33 days-of-age, all the pair-wise comparisons between control and treatment birds were significant for both LVEDD and LVESD. On average, the BR variety had the smallest dilatation of the heart and lowest mortality at 33 days-of-age when compared to other varieties. The results described in this thesis show, for the first time, variety differences in the turkey's response to diets containing furazolidone. They provide strong evidence that, like previous reports for idiopathic DCM, an animal's response to Fz-induced DCM has a strong genetic component.en_US
dc.publisherVirginia Techen_US
dc.relation.haspartThesis-KBGyenai2.pdfen_US
dc.rightsI hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Virginia Tech or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report.en_US
dc.subjectDilated cardiomyopathyen_US
dc.subjectGeneticsen_US
dc.subjectTurkeysen_US
dc.titleGenetic Analysis of Toxin-Induced Dilated Cardiomyopathy in the Turkey (Meleagris gallopavo)en_US
dc.typeThesisen_US
dc.contributor.departmentAnimal and Poultry Sciencesen_US
dc.description.degreeMaster of Scienceen_US
thesis.degree.nameMaster of Scienceen_US
thesis.degree.levelmastersen_US
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen_US
thesis.degree.disciplineAnimal and Poultry Sciencesen_US
dc.contributor.committeechairSmith, Edward J.en_US
dc.contributor.committeememberSponenberg, Daniel Phillipen_US
dc.contributor.committeememberPyle, Robert Leeen_US
dc.contributor.committeememberPierson, Frank Williamen_US
dc.contributor.committeememberLarsen, Calvert T.en_US
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-08142005-160658/en_US
dc.date.sdate2005-08-14en_US
dc.date.rdate2005-08-25
dc.date.adate2005-08-25en_US


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