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dc.contributor.authorBernardo, Jesse Raymonden_US
dc.description.abstractUnlike traditional stochastic scaffold fabrication techniques, additive manufacturing (AM) can be used to create tissue-specific three-dimensional scaffolds with controlled porosity and pore geometry (meso-structure). However, due to the relatively few biocompatible materials available for processing in AM machines, direct fabrication of tissue scaffolds is limited. To alleviate material limitations and improve feature resolution, a new indirect scaffold fabrication method is developed. A four step fabrication process is explored: Fused Deposition Modeling (FDM) is used to fabricate scaffold patterns of varied pore size and geometry. Next, scaffold patterns are surface treated, and then mineralized via simulated body fluid (SBF); forming a bone-like ceramic throughout the scaffold pattern. Finally, mineralized patterns are heat treated to pyrolyze the pattern and sinter the minerals. Two scaffold meso-structures are tested: â tubeâ and â backfill.â Two pattern materials are tested [acrylonitrile butadiene styrene (ABS) and investment cast wax (ICW)] to determine which material is the most appropriate for mineralization and sintering. Mineralization is improved through plasma surface treatment and dynamic flow conditions. Appropriate burnout and sintering temperatures to remove pattern material are determined experimentally. While the â tube scaffoldsâ were found to fail structurally, â backfill scaffoldsâ were successfully created using the new fabrication process. The â backfill scaffoldâ meso-structure had wall thicknesses of 470 â 530 µm and internal channel diameters of 280 â 340 µm, which is in the range of appropriate pore size for bone tissue engineering. â Backfill scaffoldsâ alleviated material limitations, and had improved feature resolution compared to current indirect scaffold fabrication processes.en_US
dc.publisherVirginia Techen_US
dc.rightsI hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Virginia Tech or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report.en_US
dc.subjectFused Deposition Modelingen_US
dc.subjectAdditive Manufacturingen_US
dc.subjectTissue Scaffolden_US
dc.titleIndirect Tissue Scaffold Fabrication via Additive Manufacturing and Biomimetic Mineralizationen_US
dc.contributor.departmentMechanical Engineeringen_US
dc.description.degreeMaster of Scienceen_US
thesis.degree.nameMaster of Scienceen_US
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen_US
thesis.degree.disciplineMechanical Engineeringen_US
dc.contributor.committeechairWilliams, Christopher Bryanten_US
dc.contributor.committeememberGoldstein, Aaron S.en_US
dc.contributor.committeememberBohn, Jan Helgeen_US
dc.contributor.committeememberMorgan, Abby W.en_US

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