Controlled cross circulation was performed in six pairs of dogs to assess hemodynamic changes in the donor dog. Cardiopulmonary bypass was performed for 45 minutes, with an aortic cross clamp time of 3 5 minutes. Anesthesia was maintained in the donor dog with 1.8% end-tidal isoflurane. Parameters before and after controlled cross circulation were compared using a Wilcoxon Signed Rank Test.

Donor left ventricular dP/dt max, pulmonary capillary wedge pressure, blood volume, systemic vascular resistance, heart rate, total protein, platelet count, and white blood cell count did not change significantly. Donor cardiac output, end diastolic volume, central venous pressure, stroke volume, mean arterial blood pressure, and packed cell volume all decreased significantly (p<O.05). Recipient blood volume and donor cardiac performance (LV dP/dt max/end diastolic volume) increased significantly (p<O.05).