Virginia Tech
    • Log in
    View Item 
    •   VTechWorks Home
    • Virginia-Maryland College of Veterinary Medicine (VMCVM)
    • Department of Biomedical Sciences and Pathobiology
    • Scholarly Works, Department of Biomedical Sciences and Pathobiology
    • View Item
    •   VTechWorks Home
    • Virginia-Maryland College of Veterinary Medicine (VMCVM)
    • Department of Biomedical Sciences and Pathobiology
    • Scholarly Works, Department of Biomedical Sciences and Pathobiology
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Transplacental transmission of a North American isolate of Leishmania infantum in an experimentally infected beagle

    Thumbnail
    View/Open
    Main article (56.09Kb)
    Downloads: 652
    Date
    2005-08
    Author
    Rosypal, A. C.
    Troy, Gregory C.
    Zajac, Anne M.
    Frank, G.
    Lindsay, David S.
    Metadata
    Show full item record
    Abstract
    Leishmania infantum, an etiologic agent of zoonotic visceral leishmaniasis, is widespread among foxhounds in the United States. Although sand flies are widely distributed throughout the United States, epidemiological data do not support a major role for sand flies in the transmission of L. infantum in foxhounds in this country. Congenital transmission of human visceral leishmaniasis is reported in humans and might also occur in dogs. We have previously isolated L. infantum from Virginia foxhounds and used this isolate (LIVT-1) to experimentally infect beagles. Four female beagles, chronically infected with LIVT-I, were bred to a male beagle chronically infected with L. infantum chagasi. One beagle was able to maintain her pregnancy, and 4 puppies were delivered by cesarean section. One puppy was malformed and autolytic at delivery, and tissues were not collected or analyzed. The remaining puppies were killed at the time of cesarean section, and selected tissues were collected for parasite culture and PCR. Promastigotes were not cultured from tissues in any of the puppies. Leishmania sp. DNA was detectable by PCR in liver, bone marrow, and heart from all 3 puppies and in the spleen, lymph node, kidney, and placenta in 2 puppies. Placental tissue from the dam was PCR negative. This is the first report of maternal transmission of a North American isolate of L. infantum from an experimentally infected dog.
    URI
    http://hdl.handle.net/10919/49092
    Collections
    • Scholarly Works, Department of Biomedical Sciences and Pathobiology [464]
    • Scholarly Works, Department of Small Animal Clinical Sciences [84]

    If you believe that any material in VTechWorks should be removed, please see our policy and procedure for Requesting that Material be Amended or Removed. All takedown requests will be promptly acknowledged and investigated.

    Virginia Tech | University Libraries | Contact Us
     

     

    VTechWorks

    AboutPoliciesHelp

    Browse

    All of VTechWorksCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    Log inRegister

    Statistics

    View Usage Statistics

    If you believe that any material in VTechWorks should be removed, please see our policy and procedure for Requesting that Material be Amended or Removed. All takedown requests will be promptly acknowledged and investigated.

    Virginia Tech | University Libraries | Contact Us