This research was focused on increasing the efficiency of upland cotton production in the northern cotton belt through the use of new fertilizer formulations, placement, and timings. The objectives of the experiments reported in this thesis were to: 1) evaluate the effects of side-dress potassium (K), sulfur (S), and boron (B) formulation and application timing on tissue nutrient levels during the bloom period; 2) evaluate lint yield response of cotton to different formulations of nitrogen (N), K, S and B applied at side-dress; and 3) compare 5x5 banding (5 cm beside and 5cm below the seed) and deep placement of complete N-P-K-S blends to current nutrient management strategies on early season plant growth, nodes above white flower, total nodes, petiole nutrient concentrations during bloom, and lint yield. Tissue S and B concentrations were increased more often than K concentrations when the nutrients were applied with side-dress N. When evaluating P and K placement, petiole P levels were found to be significantly higher in unfertilized plots when no side-dress N was applied. Phosphorus and K placement and/or rate had no effect on lint yield when N was applied at side-dress during the study. Environmental conditions potentially influenced the response to P and K placement as 5x5 placement produced yields significantly higher during 2013 growing season at location 1, while deep placement produced significantly higher yields in 2014 at location 3. As a result, Virginia nutrient management recommendations for cotton have been updated to incorporate management strategies to maximize lint yields.