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dc.contributor.authorPalmisano, Alidaen_US
dc.contributor.authorHoops, Stefanen_US
dc.contributor.authorWatson, Layne T.en_US
dc.contributor.authorJones, Thomas C.en_US
dc.contributor.authorTyson, John J.en_US
dc.contributor.authorShaffer, Clifford A.en_US
dc.date.accessioned2016-12-09T21:43:42Z
dc.date.available2016-12-09T21:43:42Z
dc.date.issued2015-12-24en_US
dc.identifier.citationBMC Systems Biology. 2015 Dec 24;9(1):95
dc.identifier.issn1752-0509en_US
dc.identifier.urihttp://hdl.handle.net/10919/73647
dc.description.abstractBackground Most biomolecular reaction modeling tools allow users to build models with a single list of parameter values. However, a common scenario involves different parameterizations of the model to account for the results of related experiments, for example, to define the phenotypes for a variety of mutations (gene knockout, over expression, etc.) of a specific biochemical network. This scenario is not well supported by existing model editors, forcing the user to manually generate, store, and maintain many variations of the same model. Results We developed an extension to our modeling editor called the JigCell Run Manager (JC-RM). JC-RM allows the modeler to define a hierarchy of parameter values, simulations, and plot settings, and to save them together with the initial model. JC-RM supports generation of simulation plots, as well as export to COPASI and SBML (L3V1) for further analysis. Conclusions Developing a model with its initial list of parameter values is just the first step in modeling a biological system. Models are often parameterized in many different ways to account for mutations of the organism and/or for sets of related experiments performed on the organism. JC-RM offers two critical features: it supports the everyday management of a large model, complete with its parameterizations, and it facilitates sharing this information before and after publication. JC-RM allows the modeler to define a hierarchy of parameter values, simulation, and plot settings, and to maintain a relationship between this hierarchy and the initial model. JC-RM is implemented in Java and uses the COPASI API. JC-RM runs on all major operating systems, with minimal system requirements. Installers, source code, user manual, and examples can be found at the COPASI website (http://www.copasi.org/Projects).
dc.format.extent? - ? (10) page(s)en_US
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.publisherBiomed Central Ltden_US
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000367133500001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en_US
dc.rightsCreative Commons Attribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectMathematical & Computational Biologyen_US
dc.subjectSystems biologyen_US
dc.subjectBiological networksen_US
dc.subjectMathematical modelingen_US
dc.subjectChemical reaction systemsen_US
dc.subjectCOPASIen_US
dc.subjectSBMLen_US
dc.subjectSoftwareen_US
dc.subjectModel editoren_US
dc.subjectParameter hierarchyen_US
dc.subjectMutantsen_US
dc.subjectNETWORKSen_US
dc.subjectBUILDERen_US
dc.titleJigCell Run Manager (JC-RM): a tool for managing large sets of biochemical model parametrizationsen_US
dc.typeArticle - Refereed
dc.description.versionPublished (Publication status)en_US
dc.rights.holderPalmisano et al.
dc.title.serialBMC SYSTEMS BIOLOGYen_US
dc.identifier.doihttps://doi.org/10.1186/s12918-015-0237-0
dc.identifier.volume9en_US
dc.type.dcmitypeText
pubs.organisational-group/Virginia Tech
pubs.organisational-group/Virginia Tech/All T&R Faculty
pubs.organisational-group/Virginia Tech/Engineering
pubs.organisational-group/Virginia Tech/Engineering/COE T&R Faculty
pubs.organisational-group/Virginia Tech/Engineering/Computer Science
pubs.organisational-group/Virginia Tech/Faculty of Health Sciences
pubs.organisational-group/Virginia Tech/Science
pubs.organisational-group/Virginia Tech/Science/Biological Sciences
pubs.organisational-group/Virginia Tech/Science/COS T&R Faculty
pubs.organisational-group/Virginia Tech/University Distinguished Professors
pubs.organisational-group/Virginia Tech/University Research Institutes
pubs.organisational-group/Virginia Tech/University Research Institutes/Biocomplexity Institute
pubs.organisational-group/Virginia Tech/University Research Institutes/Biocomplexity Institute/Researchers


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Creative Commons Attribution 4.0 International
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