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dc.contributor.authorZhang, Zhenlu
dc.contributor.authorHe, Guijuan
dc.contributor.authorFilipowicz, Natalie A.
dc.contributor.authorRandall, Glenn
dc.contributor.authorBelov, George A.
dc.contributor.authorKopek, Benjamin G.
dc.contributor.authorWang, Xiaofeng
dc.date.accessioned2019-03-13T18:34:26Z
dc.date.available2019-03-13T18:34:26Z
dc.date.issued2019-02-26
dc.identifier.issn1664-302X
dc.identifier.other286
dc.identifier.urihttp://hdl.handle.net/10919/88432
dc.description.abstractMembrane association is a hallmark of the genome replication of positive-strand RNA viruses [(+)RNA viruses]. All well-studied (+)RNA viruses remodel host membranes and lipid metabolism through orchestrated virus-host interactions to create a suitable microenvironment to survive and thrive in host cells. Recent research has shown that host lipids, as major components of cellular membranes, play key roles in the replication of multiple (+)RNA viruses. This review focuses on how (+)RNA viruses manipulate host lipid synthesis and metabolism to facilitate their genomic RNA replication, and how interference with the cellular lipid metabolism affects viral replication.en_US
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.publisherFrontiers
dc.rightsCreative Commons Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleHost Lipids in Positive-Strand RNA Virus Genome Replicationen_US
dc.typeArticle - Refereed
dc.title.serialFrontiers in Microbiology
dc.identifier.doihttps://doi.org/10.3389/fmicb.2019.00286
dc.identifier.volume10
dc.type.dcmitypeText


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Creative Commons Attribution 4.0 International
License: Creative Commons Attribution 4.0 International