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dc.contributor.authorSuarez-Esquivel, Marcela
dc.contributor.authorRuiz-Villalobos, Nazareth
dc.contributor.authorCastillo-Zeledon, Amanda
dc.contributor.authorJimenez-Rojas, Cesar
dc.contributor.authorRoop, R. Martin, II
dc.contributor.authorComerci, Diego J.
dc.contributor.authorBarquero-Calvo, Elias
dc.contributor.authorChacon-Diaz, Carlos
dc.contributor.authorCaswell, Clayton C.
dc.contributor.authorBaker, Kate S.
dc.contributor.authorChaves-Olarte, Esteban
dc.contributor.authorThomson, Nicholas R.
dc.contributor.authorMoreno, Edgardo
dc.contributor.authorLetesson, Jean J.
dc.contributor.authorDe Bolle, Xavier
dc.contributor.authorGuzman-Verri, Caterina
dc.date.accessioned2019-03-14T19:33:15Z
dc.date.available2019-03-14T19:33:15Z
dc.date.issued2016-09-29
dc.identifier.issn1664-302X
dc.identifier.other1557
dc.identifier.urihttp://hdl.handle.net/10919/88449
dc.description.abstractBrucellosis is a bacterial infectious disease affecting a wide range of mammals and a neglected zoonosis caused by species of the genetically homogenous genus Brucella. As in most studies on bacterial diseases, research in brucellosis is carried out by using reference strains as canonical models to understand the mechanisms underlying host pathogen interactions. We performed whole genome sequencing analysis of the reference strain B. abortus 2308 routinely used in our laboratory, including manual curated annotation accessible as an editable version through a link at https://en.wikipedia.org/wiki/Brucella#Genomics. Comparison of this genome with two publically available 2308 genomes showed significant differences, particularly indels related to insertional elements, suggesting variability related to the transposition of these elements within the same strain. Considering the outcome of high resolution genomic techniques in the bacteriology field, the conventional concept of strain definition needs to be revised.en_US
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.publisherFrontiers
dc.rightsCreative Commons Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleBrucella abortus Strain 2308 Wisconsin Genome: Importance of the Definition of Reference Strainsen_US
dc.typeArticle - Refereed
dc.title.serialFrontiers in Microbiology
dc.identifier.doihttps://doi.org/10.3389/fmicb.2016.01557
dc.identifier.volume7
dc.type.dcmitypeText
dc.identifier.pmid27746773


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Creative Commons Attribution 4.0 International
License: Creative Commons Attribution 4.0 International