Mechanical High-Intensity Focused Ultrasound (Histotripsy) in Dogs with Spontaneously Occurring Soft Tissue Sarcomas

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dc.contributor.authorRuger, Lauren N.en
dc.contributor.authorYang, Esteren
dc.contributor.authorGannon, Jessicaen
dc.contributor.authorSheppard, Hannahen
dc.contributor.authorCoutermarsh-Ott, Sherylen
dc.contributor.authorZiemlewicz, Timothy J.en
dc.contributor.authorDervisis, Nikolaos G.en
dc.contributor.authorAllen, Irving C.en
dc.contributor.authorDaniel, Gregory B.en
dc.contributor.authorTuohy, Joanne L.en
dc.contributor.authorVlaisavljevich, Elien
dc.contributor.authorKlahn, Shawna L.en
dc.date.accessioned2023-03-01T17:34:56Zen
dc.date.available2023-03-01T17:34:56Zen
dc.date.issued2023-03en
dc.date.updated2023-03-01T15:33:27Zen
dc.description.abstractIntroduction: Histotripsy is a non-invasive focused ultrasound therapy that uses controlled acoustic cavitation to mechanically disintegrate tissue. To date, there are no reports investigating histotripsy for the treatment of soft tissue sarcoma (STS). Objective: This study aimed to investigate the in vivo feasibility of ablating STS with histotripsy and to characterize the impact of partial histotripsy ablation on the acute immunologic response in canine patients with spontaneous STS. Methods: A custom 500 kHz histotripsy system was used to treat ten dogs with naturally occurring STS. Four to six days after histotripsy, tumors were surgically resected. Safety was determined by monitoring vital signs during treatment and post-treatment physical examinations, routine lab work, and owners’ reports. Ablation was characterized using radiologic and histopathologic analyses. Systemic immunological impact was evaluated by measuring changes in cytokine concentrations, and tumor microenvironment changes were evaluated by characterizing changes in infiltration with tumor-associated macrophages (TAMs) and tumor-infiltrating lymphocytes (TILs) using multiplex immunohistochemistry and differential gene expression. Results: Results showed histotripsy ablation was achievable and well-tolerated in all ten dogs. Immunological results showed histotripsy induced pro-inflammatory changes in the tumor microenvironment. Conclusion & Significance: Overall, this study demonstrates histotripsy's potential as a precise, non-invasive treatment for STS.en
dc.description.versionPublished versionen
dc.format.extentPages 768-779en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1109/TBME.2022.3201709en
dc.identifier.eissn1558-2531en
dc.identifier.issn0018-9294en
dc.identifier.issue3en
dc.identifier.orcidVlaisavljevich, Eli [0000-0002-4097-6257]en
dc.identifier.orcidAllen, Irving [0000-0001-9573-5250]en
dc.identifier.orcidDervisis, Nikolaos [0000-0003-2869-1483]en
dc.identifier.orcidTuohy, Joanne [0000-0003-1516-3841]en
dc.identifier.pmid36006886en
dc.identifier.urihttp://hdl.handle.net/10919/114018en
dc.identifier.volume70en
dc.language.isoenen
dc.publisherIEEEen
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/36006886en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectBiomedical Imagingen
dc.subjectCanceren
dc.titleMechanical High-Intensity Focused Ultrasound (Histotripsy) in Dogs with Spontaneously Occurring Soft Tissue Sarcomasen
dc.title.serialIEEE Transactions on Biomedical Engineeringen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherJournal Articleen
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Engineeringen
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Biomedical Sciences and Pathobiologyen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Small Animal Clinical Sciencesen
pubs.organisational-group/Virginia Tech/Engineering/Biomedical Engineering and Mechanicsen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Engineering/COE T&R Facultyen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/CVM T&R Facultyen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicineen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Internal Medicineen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Surgeryen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Basic Scienceen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Basic Science/Basic Scienceen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Basic Science/Basic Science/Secondary Appointment-Basic Scienceen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Basic Science/Secondary Appointment-Basic Scienceen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Internal Medicine/Secondary Appointment- Internal Medicineen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Internal Medicine/Internal Med-Subgroupen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Surgery/Secondary Appointment-Surgeryen

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