The Effects of Prednisone and Prednisone Plus Ultralow-dose Aspirin on Coagulation Parameters in Healthy Dogs

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dc.contributor.authorO'Kell, Allison Louiseen
dc.contributor.committeechairGrant, David C.en
dc.contributor.committeememberWeinstein, Nicole M.en
dc.contributor.committeememberPanciera, David L.en
dc.contributor.committeememberTroy, Gregory C.en
dc.contributor.departmentVeterinary Medical Sciencesen
dc.date.accessioned2014-03-14T21:33:30Zen
dc.date.adate2012-05-07en
dc.date.available2014-03-14T21:33:30Zen
dc.date.issued2012-01-27en
dc.date.rdate2012-05-07en
dc.date.sdate2012-04-10en
dc.description.abstractObjectives: To determine the effects of prednisone and prednisone plus ultralow-dose aspirin on coagulation in healthy dogs, and to determine intra-individual variation in thromboelastography (TEG). Animals: 14 healthy experimental dogs and 10 healthy client-owned dogs Procedures: Prospective, randomized, blinded study. TEG was performed twice three days apart on each experimental dog prior to treatment and intra-individual variation was calculated. Dogs were given prednisone (2 mg/kg/day) plus aspirin (0.5 mg/kg/day) or prednisone (2 mg/kg/day) plus placebo for 14 days, after which TEG and other baseline tests were repeated. Changes from baseline between and within each group were compared using t-tests or Wilcoxon 2 sample tests. Client owned dogs had TEG performed twice three days apart to determine intra-individual variation. Results: Intra-individual variation in TEG parameters were <10% for MA (maximum amplitude) and angle. For experimental dogs, MA and fibrinogen significantly increased from baseline whereas Ly30 (percent lysis 30 minutes after MA) and antithrombin activity significantly decreased within each group. For the prednisone plus placebo group, Ly60 (percent lysis 60 minutes after MA) significantly decreased from baseline. For all parameters, there was no difference between groups for change from baseline. Conclusions and Clinical Relevance: Prednisone caused hypercoagulability in healthy dogs evidenced by increased MA and fibrinogen and decreased antithrombin activity. Concurrent use of ultra-low dose aspirin had no effect on measured TEG parameters. Intra-individual variation in some TEG parameters is high and may preclude routine clinical utility.en
dc.description.degreeMaster of Scienceen
dc.identifier.otheretd-04102012-124404en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-04102012-124404/en
dc.identifier.urihttp://hdl.handle.net/10919/42014en
dc.publisherVirginia Techen
dc.relation.haspartOKell_AO_T_2012.pdfen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectthromboelastographyen
dc.subjecthypercoagulabilityen
dc.subjectcanineen
dc.titleThe Effects of Prednisone and Prednisone Plus Ultralow-dose Aspirin on Coagulation Parameters in Healthy Dogsen
dc.typeThesisen
thesis.degree.disciplineVeterinary Medical Sciencesen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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