Human norovirus animal model essential for vaccine development

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dc.contributor.authorYuan, Lijuanen
dc.contributor.authorParreño, Vivianaen
dc.contributor.authorRamesh, Ashwinen
dc.date.accessioned2021-12-30T17:28:38Zen
dc.date.available2021-12-30T17:28:38Zen
dc.date.issued2021-12-29en
dc.date.updated2021-12-30T17:28:36Zen
dc.description.abstractHuman noroviruses are the most common cause of acute gastroenteritis and represent an incredibly high burden on the healthcare sector. Currently no vaccines or drugs exist to prevent or treat the disease. This is in part due to a lack of animal models. Here, Dr Lijuan Yuan and the team at Virginia Polytechnic Institute and State University developed and validated gnotobiotic pigs as an animal model for the human norovirus GII.4/2003 Cin-2. Determining dose-response relationships as well as the median infectious dose, by using different statistical approaches for this virus, means we are one step closer on the path to vaccine development.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.orcidYuan, Lijuan [0000-0003-0709-5228]en
dc.identifier.urihttp://hdl.handle.net/10919/107292en
dc.language.isoenen
dc.publisherResearch Featuresen
dc.relation.urihttp://researchfeatures.com/en
dc.relation.urihttps://researchfeatures.com/human-norovirus-animal-model-essential-vaccine-development/en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.titleHuman norovirus animal model essential for vaccine developmenten
dc.typeArticleen
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Biomedical Sciences and Pathobiologyen
pubs.organisational-group/Virginia Tech/University Research Institutesen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciencesen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/CVM T&R Facultyen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciences/Durelle Scotten

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Destination Area: Global Systems Science (GSS)
Scholarly Works, Biomedical Sciences and Pathobiology