Cardiovascular components of organophosphorus-induced delayed neuropathy

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dc.contributor.authorMcCain, Wilfred C.en
dc.contributor.departmentVeterinary Medical Sciencesen
dc.date.accessioned2014-03-14T21:32:00Zen
dc.date.adate2010-03-17en
dc.date.available2014-03-14T21:32:00Zen
dc.date.issued1991en
dc.date.rdate2010-03-17en
dc.date.sdate2010-03-17en
dc.description.abstractThe focus of this study was to assess the cardiovascular effects in hens of a single 2.5 mg/kg intramuscular injection of phenyl saligenin phosphate (PSP) into the breast muscle. Parameters were measured at 1, 3, 7, and 20 days post treatment. All hens developed clinical signs of delayed neuropathy by day 10 and these signs were maximal by day 20. Alterations of measured parameters were observed prior to the onset of clinical signs of organophosphorus-induced delayed neuropathy (OPIDN) (days 1, 3, and 7) as well as when maximal clinical signs were evident (days 15-21). Significant decreases in the activities of brain NTE and plasma cholinesterase as well as decreases in weight and the level of pcO2 and an increase in peripheral resistance were observed prior to evidence of clinical signs of OPIDN. When maximal signs of OPIDN were present, brain NTE and plasma cholinesterase were at control levels but brain cholinesterase was significantly increased. Significant decreases in body weight and arterial pCO2 and significant increases in limb venous flow, arterial blood pressure, and hematocrit were seen at this time.en
dc.description.degreeMaster of Scienceen
dc.format.extentix, 74 leavesen
dc.format.mediumBTDen
dc.format.mimetypeapplication/pdfen
dc.identifier.otheretd-03172010-020435en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-03172010-020435/en
dc.identifier.urihttp://hdl.handle.net/10919/41691en
dc.language.isoenen
dc.publisherVirginia Techen
dc.relation.haspartLD5655.V855_1991.M441.pdfen
dc.relation.isformatofOCLC# 24957073en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subject.lccLD5655.V855 1991.M441en
dc.subject.lcshNervous system -- Diseasesen
dc.subject.lcshNeuropathyen
dc.titleCardiovascular components of organophosphorus-induced delayed neuropathyen
dc.typeThesisen
dc.type.dcmitypeTexten
thesis.degree.disciplineVeterinary Medical Sciencesen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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