Incidental diagnosis of a spindle cell type gastrointestinal stromal tumor in a dog with ethylene glycol intoxication

dc.contributor.authorSerpa, Priscila B. S.en
dc.contributor.authorSantos, Andrea P.en
dc.date.accessioned2022-01-06T17:03:46Zen
dc.date.available2022-01-06T17:03:46Zen
dc.date.issued2021-11-21en
dc.date.updated2022-01-06T17:03:44Zen
dc.description.abstractA 6-year-old castrated male American Pit Bull Terrier dog was presented for evaluation of acute onset of tonic-clonic seizures, anorexia, and vomiting. On physical examination, neurologic signs, such as generalized proprioceptive ataxia, salivation, circling to the right, and absent patellar reflexes bilaterally, were noted. A complete blood cell count revealed mild hemoconcentration and an inflammatory leukogram, while a chemistry panel showed severe azotemia, marked hypochloremia, and a severe titrational metabolic acidosis, suggesting possible ethylene glycol intoxication. However, an irregularly round, small mass was identified in the large intestine on abdominal ultrasound. Additionally, bilateral hyperechoic renal cortices with medullary rim sign were suggestive of acute nephritis or tubular necrosis. The cytologic evaluation of a fine-needle aspiration biopsy of the abdominal mass revealed a large population of mesenchymal cells, suggesting the presence of neoplasia. Due to the worsening of symptoms, the dog was humanely euthanized. Necropsy confirmed ethylene glycol intoxication, and the incidental finding of a neoplastic intestinal mass was diagnosed as spindle cell sarcoma. Immunohistochemical staining showed strong, diffuse positivity for CD117, smooth muscle actin, and S-100, indicating the final diagnosis of a spindle cell type gastrointestinal stromal tumor (GIST). This report briefly discusses the classifications of nonlymphoid, nonangiogenic intestinal mesenchymal tumors, characteristics of GISTs, and the importance of the immunohistochemical classification of mesenchymal tumors of the gastrointestinal tract.en
dc.description.versionAccepted versionen
dc.format.extent6 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1111/vcp.13063en
dc.identifier.eissn1939-165Xen
dc.identifier.issn0275-6382en
dc.identifier.orcidda Silva Serpa, Priscila Beatriz [0000-0001-6073-2172]en
dc.identifier.pmid34806207en
dc.identifier.urihttp://hdl.handle.net/10919/107429en
dc.language.isoenen
dc.publisherWileyen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000720780200001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectLife Sciences & Biomedicineen
dc.subjectVeterinary Sciencesen
dc.subjectcanineen
dc.subjectCD117en
dc.subjectcytologyen
dc.subjectGISTen
dc.subjectimmunohistochemistryen
dc.subjectneoplasiaen
dc.subjectNIMTen
dc.subjectEXPRESSIONen
dc.subject0608 Zoologyen
dc.subject0707 Veterinary Sciencesen
dc.titleIncidental diagnosis of a spindle cell type gastrointestinal stromal tumor in a dog with ethylene glycol intoxicationen
dc.title.serialVeterinary Clinical Pathologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherArticleen
dc.type.otherEarly Accessen
dc.type.otherJournalen
dcterms.dateAccepted2021-07-31en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Biomedical Sciences and Pathobiologyen
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