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Study of podophyllotoxin biosynthesis in Podophyllum species

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dc.contributor.authorBaur, Wendy L.en
dc.contributor.committeechairLewis, Norman G.en
dc.contributor.committeechairHess, John L.en
dc.contributor.committeememberKingston, David G. I.en
dc.contributor.departmentWood Science and Forest Productsen
dc.date.accessioned2014-03-14T21:31:12Zen
dc.date.adate2009-03-12en
dc.date.available2014-03-14T21:31:12Zen
dc.date.issued1990-06-06en
dc.date.rdate2009-03-12en
dc.date.sdate2009-03-12en
dc.description.abstractLignans are a structurally diverse group of phenylpropanoid metabolites widely distributed throughout the plant kingdom. Their biogenetic pathway has generally been viewed to occur via coupling of two monomeric moieties, with subsequent modifications as required to afford the various Iignan skeleton structures. Podophyllotoxin is a tetrahydronaphthalene lignan found in Podophyllum species, and its derivative etoposide is widely used medicinally for skin cancer and venereal warts (Condyloma acuminatum). In this investigation, the biogenetic pathway to podophyllotoxin was investigated using whole plants, as well as callus and rhizome tissue. In contrast to previous claims in the literature, no active metabolism leading to podophyllotoxin formation in vivo in callus culture was observed. Similar findings were also noted for rhizome tissue. With whole plants, experiments investigating podophyllotoxin formation have been limited to employing lignan substrates, labeled specifically with carbon-14 and tritium. No stable isotopes, e.g carbon-13 or deuterium, have been used because of low incorporations.en
dc.description.degreeMaster of Scienceen
dc.format.extentx, 95 leavesen
dc.format.mediumBTDen
dc.format.mimetypeapplication/pdfen
dc.identifier.otheretd-03122009-040904en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-03122009-040904/en
dc.identifier.urihttp://hdl.handle.net/10919/41488en
dc.language.isoenen
dc.publisherVirginia Techen
dc.relation.haspartLD5655.V855_1990.B386.pdfen
dc.relation.isformatofOCLC# 23603676en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subject.lccLD5655.V855 1990.B386en
dc.subject.lcshLigninen
dc.subject.lcshPodophyllumen
dc.titleStudy of podophyllotoxin biosynthesis in Podophyllum speciesen
dc.typeThesisen
dc.type.dcmitypeTexten
thesis.degree.disciplineWood Science and Forest Productsen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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