Nutrition Support and Newborn Screening in the NICU Population: Is There a Link?

Simple item page
dc.contributor.authorCochran, Brittany Paigeen
dc.contributor.committeechairClark, Susan F.en
dc.contributor.committeememberGoodin, Barbaraen
dc.contributor.committeememberHosig, Kathryn W.en
dc.contributor.departmentHuman Nutrition, Foods, and Exerciseen
dc.date.accessioned2017-04-04T19:49:02Zen
dc.date.adate2010-06-02en
dc.date.available2017-04-04T19:49:02Zen
dc.date.issued2010-05-03en
dc.date.rdate2016-09-27en
dc.date.sdate2010-05-14en
dc.description.abstractBackground: Recent research is revealing the high rate of false-positive screening results for IEMs in the NICU population. No study published to date has specifically studied the possible relationship between nutrition and newborn screening in this population. Objective: It is suspected that NICU infants who receive PN are more likely to have abnormal newborn screening results than infants who receive EN. An understanding of the role of nutrition will assist in developing protocols for screening in the NICU and decrease false-positives. Design: Infants admitted to the NICU between January 1-June 30, 2009 were included in this retrospective chart review study (n=339). The type of nutrition and timing of its initiation was recorded and compared to newborn screening results to identify correlations with false-positives. Statistical analysis included means, percentages, Fisher's exact test, Chi-square test, and the Cochran-Mantel-Haenszel test. Results: Nutrition type was significantly associated with newborn screening (p<0.001); those who received parenteral nutrition were more likely to have a false-positive. For infants who also received PN, EN of breast milk exclusively increased risk of an abnormal screen more than formula exclusively or breast milk plus formula. The timing of parenteral nutrition had no effect on screening. Premature infants who received PN exclusively had a higher percentage of false-positives than those who received EN Conclusions: Although the hypothesis could not be statistically supported, PN appears to contribute to false-positive newborn screens. More research is needed to ascertain the role of EN and GA in newborn screening and to develop standardized protocols.en
dc.description.degreeMaster of Scienceen
dc.identifier.otheretd-05142010-215019en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-05142010-215019/en
dc.identifier.urihttp://hdl.handle.net/10919/76756en
dc.language.isoen_USen
dc.publisherVirginia Techen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectParenteral Nutritionen
dc.subjectNewborn Screeningen
dc.subjectNICUen
dc.subjectPreterm Infanten
dc.subjectInborn Errors of Metabolismen
dc.titleNutrition Support and Newborn Screening in the NICU Population: Is There a Link?en
dc.typeThesisen
dc.type.dcmitypeTexten
thesis.degree.disciplineHuman Nutrition, Foods, and Exerciseen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
etd-05142010-215019_Cochran_BP_T_2010.pdf
Size:
1.43 MB
Format:
Adobe Portable Document Format
Download

Collections

Masters Theses