Age-Related Intrinsic Functional Connectivity Changes of Locus Coeruleus from Childhood to Older Adults

Simple item page
dc.contributor.authorSong, Inuken
dc.contributor.authorNeal, Joshuaen
dc.contributor.authorLee, Tae-Hoen
dc.date.accessioned2021-11-11T19:23:41Zen
dc.date.available2021-11-11T19:23:41Zen
dc.date.issued2021-11-10en
dc.date.updated2021-11-11T14:58:00Zen
dc.description.abstractThe locus coeruleus is critical for selective information processing by modulating the brain’s connectivity configuration. Increasingly, studies have suggested that LC controls sensory inputs at the sensory gating stage. Furthermore, accumulating evidence has shown that young children and older adults are more prone to distraction and filter out irrelevant information less efficiently, possibly due to the unoptimized LC connectivity. However, the LC connectivity pattern across the life span is not fully examined yet, hampering our ability to understand the relationship between LC development and the distractibility. In this study, we examined the intrinsic network connectivity of the LC using a public fMRI dataset with wide-range age samples. Based on LC-seed functional connectivity maps, we examined the age-related variation in the LC connectivity with a quadratic model. The analyses revealed two connectivity patterns explicitly. The sensory-related brain regions showed a positive quadratic age effect (u-shape), and the frontal regions for the cognitive control showed a negative quadratic age effect (inverted u-shape). Our results imply that such age-related distractibility is possibly due to the impaired sensory gating by the LC and the insufficient top-down controls by the frontal regions. We discuss the underlying neural mechanisms and limitations of our study.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationSong, I.; Neal, J.; Lee, T.-H. Age-Related Intrinsic Functional Connectivity Changes of Locus Coeruleus from Childhood to Older Adults. Brain Sci. 2021, 11, 1485.en
dc.identifier.doihttps://doi.org/10.3390/brainsci11111485en
dc.identifier.urihttp://hdl.handle.net/10919/106612en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectlocus coeruleusen
dc.subjectdistractibilityen
dc.subjectneurodevelopmenten
dc.subjectfunctional connectivityen
dc.titleAge-Related Intrinsic Functional Connectivity Changes of Locus Coeruleus from Childhood to Older Adultsen
dc.title.serialBrain Scienceen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
brainsci-11-01485-v2.pdf
Size:
1.16 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
Name:
license.txt
Size:
0 B
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Journal Articles, Multidisciplinary Digital Publishing Institute (MDPI)
Destination Area: Adaptive Brain and Behavior (ABB)
Scholarly Works, Psychology
Scholarly Works, School of Neuroscience