Neural cognitive control moderates the longitudinal link between hedonia and substance use across adolescence

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dc.contributor.authorLindenmuth, Morganen
dc.contributor.authorHerd, Toriaen
dc.contributor.authorBrieant, Alexisen
dc.contributor.authorLee, Jacoben
dc.contributor.authorDeater-Deckard, Kirbyen
dc.contributor.authorBickel, Warren K.en
dc.contributor.authorCasas, Brooksen
dc.contributor.authorKim-Spoon, Jungmeenen
dc.date.accessioned2022-09-27T12:46:01Zen
dc.date.available2022-09-27T12:46:01Zen
dc.date.issued2022-06-01en
dc.date.updated2022-09-26T19:24:04Zen
dc.description.abstractHedonic dysregulation is evident in addiction and substance use disorders, but it is not clearly understood how hedonic processes may interact with brain development related to cognitive control to influence risky decision making and substance use during adolescence. The present study used prospective longitudinal data to clarify the role of cognitive control in the link between hedonic experiences and the development of substance use during adolescence. Participants included 167 adolescents (53% male) assessed at four time points, annually. Adolescents participated in a functional magnetic resonance imaging (fMRI) session where blood-oxygen level dependent (BOLD) response was monitored during the Multi-Source- Interference Task to assess cognitive control. Substance use and hedonia were assessed using self-report. A two-group growth curve model of substance use with hedonia as a time-varying covariate indicated that higher levels of hedonia predicted higher substance use, but only in adolescents with higher activation in the frontoparietal regions and in the rostral anterior cingulate cortex during cognitive control. Results elucidate the moderating effects of neural cognitive control on associations between hedonia and adolescent substance use, suggesting that lower cognitive control functioning in the brain may exacerbate risk for substance use promoted by hedonia.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier101111 (Article number)en
dc.identifier.doihttps://doi.org/10.1016/j.dcn.2022.101111en
dc.identifier.eissn1878-9307en
dc.identifier.issn1878-9293en
dc.identifier.orcidKim-Spoon, Jungmeen [0000-0003-0581-2019]en
dc.identifier.orcidBickel, Warren [0000-0002-1048-7372]en
dc.identifier.otherS1878-9293(22)00054-8 (PII)en
dc.identifier.pmid35472691en
dc.identifier.urihttp://hdl.handle.net/10919/112007en
dc.identifier.volume55en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/35472691en
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectAdolescenceen
dc.subjectCognitive controlen
dc.subjectFunctional neuroimagingen
dc.subjectHedoniaen
dc.subjectSubstance useen
dc.subjectBrain Disordersen
dc.subjectMental Healthen
dc.subjectSubstance Abuseen
dc.subjectNeurosciencesen
dc.subjectClinical Researchen
dc.subjectPediatricen
dc.subjectBehavioral and Social Scienceen
dc.subjectBasic Behavioral and Social Scienceen
dc.subjectDrug Abuse (NIDA Only)en
dc.subject2 Aetiologyen
dc.subject2.3 Psychological, social and economic factorsen
dc.subject1 Underpinning researchen
dc.subject1.1 Normal biological development and functioningen
dc.subjectNeurologicalen
dc.subject3 Good Health and Well Beingen
dc.subject.meshBrainen
dc.subject.meshHumansen
dc.subject.meshSubstance-Related Disordersen
dc.subject.meshMagnetic Resonance Imagingen
dc.subject.meshProspective Studiesen
dc.subject.meshCognitionen
dc.subject.meshAdolescenten
dc.subject.meshFemaleen
dc.subject.meshMaleen
dc.titleNeural cognitive control moderates the longitudinal link between hedonia and substance use across adolescenceen
dc.title.serialDevelopmental Cognitive Neuroscienceen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherJournal Articleen
dcterms.dateAccepted2022-04-14en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Scienceen
pubs.organisational-group/Virginia Tech/Science/Psychologyen
pubs.organisational-group/Virginia Tech/University Research Institutesen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciencesen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Science/COS T&R Facultyen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciences/Durelle Scotten
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicineen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Psychiatry and Behavioral Medicineen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Psychiatry and Behavioral Medicine/Secondary Appointment-Psychiatry and Behavioral Medicineen

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