Transparent and Sprayable Surface Coatings that Kill Drug-Resistant Bacteria within Minutes and Inactivate SARS-CoV-2 Virus

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dc.contributor.authorBehzadinasab, Saeeden
dc.contributor.authorWilliams, Myra D.en
dc.contributor.authorHosseini, Mohsenen
dc.contributor.authorPoon, Leo L. M.en
dc.contributor.authorChin, Alex W. H.en
dc.contributor.authorFalkinham, Joseph O. IIIen
dc.contributor.authorDucker, William A.en
dc.date.accessioned2022-02-06T21:57:46Zen
dc.date.available2022-02-06T21:57:46Zen
dc.date.issued2021-11-24en
dc.date.updated2022-02-06T21:57:36Zen
dc.description.abstractAntimicrobial coatings are one method to reduce the spread of microbial diseases. Transparent coatings preserve the visual properties of surfaces and are strictly necessary for applications such as antimicrobial cell phone screens. This work describes transparent coatings that inactivate microbes within minutes. The coatings are based on a polydopamine (PDA) adhesive, which has the useful property that the monomer can be sprayed, and then the monomer polymerizes in a conformal film at room temperature. Two coatings are described (1) a coating where PDA is deposited first and then a thin layer of copper is grown on the PDA by electroless deposition (PDA/Cu) and (2) a coating where a suspension of Cu2O particles in a PDA solution is deposited in a single step (PDA/Cu2O). In the second coating, PDA menisci bind Cu2O particles to the solid surface. Both coatings are transparent and are highly efficient in inactivating microbes. PDA/Cu kills >99.99% of Pseudomonas aeruginosa and 99.18% of methicillin-resistant Staphylococcus aureus (MRSA) in only 10 min and inactivates 99.98% of SARS-CoV-2 virus in 1 h. PDA/Cu2O kills 99.94% of P. aeruginosa and 96.82% of MRSA within 10 min and inactivates 99.88% of SARS-CoV-2 in 1 h.en
dc.description.versionPublished versionen
dc.format.extentPages 54706-54714en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1021/acsami.1c15505en
dc.identifier.eissn1944-8252en
dc.identifier.issn1944-8244en
dc.identifier.issue46en
dc.identifier.orcidDucker, William [0000-0002-8207-768X]en
dc.identifier.pmid34766745en
dc.identifier.urihttp://hdl.handle.net/10919/108172en
dc.identifier.volume13en
dc.language.isoenen
dc.publisherAmerican Chemical Societyen
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/34766745en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectCOVID-19en
dc.subjectSARS-CoV-2 virusen
dc.subjectantibacterialen
dc.subjectantimicrobialen
dc.subjectcoatingen
dc.subjectdrug-resistant bacteriaen
dc.subjecttransparenten
dc.subject03 Chemical Sciencesen
dc.subject09 Engineeringen
dc.subjectNanoscience & Nanotechnologyen
dc.subject.meshHumansen
dc.subject.meshPseudomonas aeruginosaen
dc.subject.meshAnti-Bacterial Agentsen
dc.subject.meshAntiviral Agentsen
dc.subject.meshDrug Resistance, Microbialen
dc.subject.meshSurface Propertiesen
dc.subject.meshMethicillin-Resistant Staphylococcus aureusen
dc.subject.meshCOVID-19en
dc.subject.meshSARS-CoV-2en
dc.titleTransparent and Sprayable Surface Coatings that Kill Drug-Resistant Bacteria within Minutes and Inactivate SARS-CoV-2 Virusen
dc.title.serialACS Applied Materials and Interfacesen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherJournal Articleen
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Engineeringen
pubs.organisational-group/Virginia Tech/Engineering/Chemical Engineeringen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Engineering/COE T&R Facultyen

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