Large scale complete genome sequencing and phylodynamic analysis of eastern equine encephalitis virus reveal source-sink transmission dynamics in the United States

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dc.contributor.authorTan, Yien
dc.contributor.authorLam, Tommy Tsan-Yuken
dc.contributor.authorHeberlein-Larson, Lea A.en
dc.contributor.authorSmole, Sandra C.en
dc.contributor.authorAuguste, Albert J.en
dc.contributor.authorHennigan, Scotten
dc.contributor.authorHalpin, Rebecca A.en
dc.contributor.authorFedorova, Nadiaen
dc.contributor.authorPuri, Vinitaen
dc.contributor.authorStockwell, Timothy B.en
dc.contributor.authorShilts, Meghan H.en
dc.contributor.authorAndreadis, Theodore G.en
dc.contributor.authorArmstrong, Philip M.en
dc.contributor.authorTesh, Robert B.en
dc.contributor.authorWeaver, Scott C.en
dc.contributor.authorUnnasch, Thomas R.en
dc.contributor.authorCiota, Alexander T.en
dc.contributor.authorKramer, Laura D.en
dc.contributor.authorDas, Suman R.en
dc.contributor.departmentEntomologyen
dc.coverage.countryUnited Statesen
dc.date.accessioned2019-01-22T18:23:57Zen
dc.date.available2019-01-22T18:23:57Zen
dc.date.issued2018-04-04en
dc.date.updated2019-01-22T18:23:53Zen
dc.description.abstractEastern equine encephalitis virus (EEEV) has a high case-fatality rate in horses and humans, and Florida has been hypothesized to be the source of EEEV epidemics for the northeastern United States. To test this hypothesis, we sequenced complete genomes of 433 EEEV strains collected within the United States from 1934 to 2014. Phylogenetic analysis suggested EEEV evolves relatively slowly and that transmission is enzootic in Florida, characterized by higher genetic diversity and long-term local persistence. In contrast, EEEV strains in New York and Massachusetts were characterized by lower genetic diversity, multiple introductions, and shorter local persistence. Our phylogeographic analysis supported a source-sink model in which Florida is the major source of EEEV compared to the other localities sampled. In sum, this study revealed the complex epidemiological dynamics of EEEV in different geographic regions in the United States and provided general insights into the evolution and transmission of other avian mosquito-borne viruses in this region.en
dc.description.versionPublished versionen
dc.format.extentPages 00074-00074en
dc.format.extent18 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.issn0022-538Xen
dc.identifier.urihttp://hdl.handle.net/10919/86831en
dc.language.isoenen
dc.publisherAmerican Society for Microbiologyen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subject06 Biological Sciencesen
dc.subject07 Agricultural And Veterinary Sciencesen
dc.subject11 Medical And Health Sciencesen
dc.subjectVirologyen
dc.titleLarge scale complete genome sequencing and phylodynamic analysis of eastern equine encephalitis virus reveal source-sink transmission dynamics in the United Statesen
dc.title.serialJournal of Virologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciencesen
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Entomologyen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/CALS T&R Facultyen

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