Measurement of Pre and Postprandial Urine Calcium to Creatinine Ratio to Identify Calcium Oxalate Urolithiasis in Miniature Schnauzers

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dc.contributor.authorCarr, Susan Vennen
dc.contributor.committeechairGrant, David C.en
dc.contributor.committeememberDemonaco, Stefanieen
dc.contributor.committeememberShepherd, Megan Leighen
dc.contributor.departmentBiomedical and Veterinary Sciencesen
dc.date.accessioned2018-06-26T08:01:39Zen
dc.date.available2018-06-26T08:01:39Zen
dc.date.issued2018-06-25en
dc.description.abstractThe intent of this research is to identify a simple diagnostic test to detect abnormal calciuresis and predict calcium oxalate (CaOx) urolith presence in Miniature Schnauzers. We investigated the impact of postprandial time on the specificity of urine calcium:creatine (UCa/Cr) in identifying affected dogs. The hypotheses were: 1) Significant differences exist in fasted and postprandial UCa/Cr between urolith-forming and control schnauzers. 2) UCa/Cr increases significantly from fasted baseline at one or more postprandial time point(s). Urine samples were collected from Miniature Schnauzers with (urolith-formers) and without (controls) CaOx uroliths in a fasted state and 1, 2, 4, and 8 hours after feeding a standardized diet. The change in UCa/Cr from baseline was calculated for each postprandial time. Urolithiasis status and the time point were assessed for impact on the UCa/Cr and change in UCa/Cr using a mixed model ANOVA. Based on 9 urolith-forming and 15 control dogs enrolled, urolith-forming Miniature Schnauzers have significantly higher mean UCa/Cr at 1 hour and 8 hours postprandial timepoints indicating altered calciuresis. The change in UCa/Cr was not significant at any post-prandial time point between or within groups. This pilot study shows male urolith-forming Miniature Schnauzers have excessive calciuresis throughout the day, providing insight into the mechanism behind their formation of CaOx uroliths. If using the Ca/Cr ratio, the postprandial sampling time is not critical. This simple urine measurement has potential as a marker of urolith presence and possibly risk of urolith formation.en
dc.description.degreeMaster of Scienceen
dc.format.mediumETDen
dc.identifier.othervt_gsexam:15345en
dc.identifier.urihttp://hdl.handle.net/10919/83768en
dc.publisherVirginia Techen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectUrolithiasisen
dc.subjectCanineen
dc.subjectVeterinaryen
dc.subjectCalcium Oxalateen
dc.subjectMiniature Schnauzeren
dc.subjectcalciuresisen
dc.titleMeasurement of Pre and Postprandial Urine Calcium to Creatinine Ratio to Identify Calcium Oxalate Urolithiasis in Miniature Schnauzersen
dc.typeThesisen
thesis.degree.disciplineBiomedical and Veterinary Sciencesen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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