Non-inflammasome forming NLRs in inflammation and tumorigenesis

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dc.contributor.authorAllen, Irving C.en
dc.date.accessioned2017-01-08T21:33:53Zen
dc.date.available2017-01-08T21:33:53Zen
dc.date.issued2014-04-22en
dc.description.abstractAberrant inflammation is an enabling characteristic of tumorigenesis. Thus, signaling cascades that alter inflammatory activation and resolution are of specific relevance to disease pathogenesis. Pattern recognition receptors (PRRs) are essential mediators of the host immune response and have emerged as critical elements affecting multiple facets of tumor pathobiology. The nucleotide-binding domain and leucine-rich repeat containing (NLR) proteins are intracellular PRRs that sense microbial and non-microbial products. Members of the NLR family can be divided into functional sub-groups based on their ability to either positively or negatively regulate the host immune response. Recent studies have identified a novel sub-group of non-inflammasome forming NLRs that negatively regulate diverse biological pathways associated with both inflammation and tumorigenesis. Understanding the mechanisms underlying the function of these unique NLRs will assist in the rationale design of future therapeutic strategies targeting a wide spectrum of inflammatory diseases and cancer. Here, we will discuss recent findings associated with this novel NLR sub-group and mechanisms by which these PRRs may function to alter cancer pathogenesis.en
dc.description.versionPublished versionen
dc.format.extent? - ? (7) page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fimmu.2014.00169en
dc.identifier.issn1664-3224en
dc.identifier.urihttp://hdl.handle.net/10919/74022en
dc.identifier.volume5en
dc.language.isoenen
dc.publisherFrontiersen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000354134500001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution 3.0 Unporteden
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/en
dc.subjectImmunologyen
dc.subjectNod-like receptorsen
dc.subjectNLRP12en
dc.subjectNLRX1en
dc.subjectNLRC3en
dc.subjectNF-kappa B,TRAFen
dc.subjectcanceren
dc.subjectpattern recognition receptorsen
dc.subjectNF-KAPPA-Ben
dc.subjectINNATE IMMUNE-SYSTEMen
dc.subjectCUTTING EDGEen
dc.subjectLISTERIA-MONOCYTOGENESen
dc.subjectSIGNALING PATHWAYSen
dc.subjectNALP3 INFLAMMASOMEen
dc.subjectCOLON INFLAMMATIONen
dc.subjectINDUCED ACTIVATIONen
dc.subjectBREAST-CARCINOMAen
dc.subjectMELANOMA-CELLSen
dc.titleNon-inflammasome forming NLRs in inflammation and tumorigenesisen
dc.title.serialFrontiers in Immunologyen
dc.typeArticle - Refereeden
dc.typeReviewen
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Biomedical Sciences and Pathobiologyen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/CVM T&R Facultyen

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