Dietary Fat and Sugar Induce Obesity and Impair Glucose Tolerance in Prepubertal Pigs

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dc.contributor.authorvan Eyk, Gregory Ryanen
dc.contributor.committeechairEscobar, Jefferyen
dc.contributor.committeememberGerrard, David E.en
dc.contributor.committeememberJiang, Honglinen
dc.contributor.committeememberScheffler, Jason M.en
dc.contributor.departmentAnimal and Poultry Sciencesen
dc.date.accessioned2014-03-14T20:37:18Zen
dc.date.adate2012-06-05en
dc.date.available2014-03-14T20:37:18Zen
dc.date.issued2012-04-30en
dc.date.rdate2012-06-05en
dc.date.sdate2012-05-16en
dc.description.abstractA pig model of childhood obesity was used to study the effects of dietary energy on body adiposity, and blood parameters associated with impaired glucose clearance. Prepubertal female pigs weaned at 21 d of age were fed control (CON), refined sugar (SUG), fat (FAT), and sugar-fat (SUGFAT) diets in a completely randomized arrangement for 16 wk. Calories from fat were 8.9% for CON, 5.6% for SUG, 35.5% for FAT and 32.3% for SUGFAT. Calories from sugar were 36.0% for SUG and 30.7% for SUGFAT. Adding fat, sugar or both to diets increased (P < 0.003) calorie intake. Percentage body fat was higher (P < 0.0001) in all treatments compared to CON, and in SUGFAT and FAT compared to SUG. Ultrasound back fat depth was positively correlated (r2 = 0.909; P < 0.001) with percentage body fat and negatively (r = 0.912; P-value ) with percentage body protein. Area under the curve (AUC) in response to oral glucose tolerance at 14 wk was higher (P < 0.03) in FAT (+14.6%) and SUGFAT (+25.5%) pigs compared to CON. Glucose AUC from sugar-fed pigs was not different (P = 0.2) from fat alone-fed pigs. Adding sugar, fat, or their combination to diets increased (P < 0.008) blood glucose and decreased (P < 0.0009) plasma insulin AUC. These data show that inclusion of fat and refined sugar in pig diets increases body adiposity and impairs glucose homeostasis and suggests that the composition of calories consumed may have different effects than simply consumption of excess of calories.en
dc.description.degreeMaster of Scienceen
dc.identifier.otheretd-05162012-233514en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-05162012-233514/en
dc.identifier.urihttp://hdl.handle.net/10919/32892en
dc.language.isoenen
dc.publisherVirginia Techen
dc.relation.haspartvanEyk_GR_T_2012.pdfen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectglucose tolerance testen
dc.subjectwhole body compositionen
dc.subjectObesityen
dc.subjectdiabetesen
dc.subjectmetabolic syndromeen
dc.titleDietary Fat and Sugar Induce Obesity and Impair Glucose Tolerance in Prepubertal Pigsen
dc.typeThesisen
thesis.degree.disciplineAnimal and Poultry Sciencesen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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