A Natural Botanical Product, Resveratrol, Effectively Suppresses Vesicular Stomatitis Virus Infection In Vitro

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dc.contributor.authorLin, Shih-Chaoen
dc.contributor.authorZhang, Xiangen
dc.contributor.authorLehman, Caitlin W.en
dc.contributor.authorPan, Han-Chien
dc.contributor.authorWen, Yaen
dc.contributor.authorChen, Shiow-Yien
dc.contributor.departmentBiomedical Sciences and Pathobiologyen
dc.date.accessioned2021-06-24T14:54:16Zen
dc.date.available2021-06-24T14:54:16Zen
dc.date.issued2021-06-17en
dc.date.updated2021-06-24T14:11:27Zen
dc.description.abstractNumerous natural phytochemicals such as resveratrol are acknowledged as potent botanical agents in regulating immune responses. However, it is less understood whether such immunomodulatory phytochemicals are appropriate for use as direct treatments in veterinary viral diseases. In the present study, we investigated the efficacy of resveratrol in suppressing vesicular stomatitis virus (VSV) infection. Outbreaks of VSV can cause massive economic loss in poultry and livestock husbandry farming, and VSV treatment is in need of therapeutic development. We utilized a recombinant VSV that expresses green fluorescent protein (GFP) to measure viral replication in cells treated with resveratrol. Our findings revealed that resveratrol treatment affords a protective effect, shown by increased viability and reduced viral replication, as indicated by a reduction in fluorescent signals. Additionally, we found that resveratrol inhibition of VSV infection occurs via suppression of the caspase cascade. Structural analysis also indicated that resveratrol potentially interacts with the active sites of caspase-3 and -7, facilitating antiviral activity. The potential effect of resveratrol on reducing VSV infection in vitro suggests that resveratrol should be further investigated as a potential veterinary therapeutic or prophylactic agent.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationLin, S.-C.; Zhang, X.; Lehman, C.W.; Pan, H.-C.; Wen, Y.; Chen, S.-Y. A Natural Botanical Product, Resveratrol, Effectively Suppresses Vesicular Stomatitis Virus Infection In Vitro. Plants 2021, 10, 1231.en
dc.identifier.doihttps://doi.org/10.3390/plants10061231en
dc.identifier.urihttp://hdl.handle.net/10919/103987en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectresveratrolen
dc.subjectvesicular stomatitis virusen
dc.subjectantiviral activityen
dc.subjectveterinary scienceen
dc.subjecthusbandry farmingen
dc.titleA Natural Botanical Product, Resveratrol, Effectively Suppresses Vesicular Stomatitis Virus Infection In Vitroen
dc.title.serialPlantsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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