Effects of Chronic Social Stress and Maternal Intranasal Oxytocin and Vasopressin on Offspring Interferon-gamma and Behavior

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dc.contributor.authorMurgatroyd, Christopher A.en
dc.contributor.authorHicks-Nelson, Alexandriaen
dc.contributor.authorFink, Alexandriaen
dc.contributor.authorBeamer, Gillianen
dc.contributor.authorGurel, Kursaten
dc.contributor.authorElnady, Fawzyen
dc.contributor.authorPittet, Florenten
dc.contributor.authorNephew, Benjamin C.en
dc.date.accessioned2020-09-21T18:57:57Zen
dc.date.available2020-09-21T18:57:57Zen
dc.date.issued2016-12-14en
dc.date.updated2020-09-21T18:57:54Zen
dc.description.abstractRecent studies support the hypothesis that the adverse effects of early-life adversity and transgenerational stress on neural plasticity and behavior are mediated by inflammation. The objective of the present study was to investigate the immune and behavioral programing effects of intranasal (IN) vasopressin (AVP) and oxytocin (OXT) treatment of chronic social stress (CSS)-exposed F1 dams on F2 juvenile female offspring. It was hypothesized that maternal AVP and OXT treatment would have preventative effects on social stress-induced deficits in offspring anxiety and social behavior and that these effects would be associated with changes in interferon-γ (IFNγ). Control and CSS-exposed F1 dams were administered IN saline, AVP, or OXT during lactation and the F2 juvenile female offspring were assessed for basal plasma IFNγ and perseverative, anxiety, and social behavior. CSS F2 female juvenile offspring had elevated IFNγ levels and exhibited increased repetitive/perseverative and anxiety behaviors and deficits in social behavior. These effects were modulated by AVP and OXT in a context- and behavior-dependent manner, with OXT exhibiting preventative effects on repetitive and anxiety behaviors and AVP possessing preventative effects on social behavior deficits and anxiety. Basal IFNγ levels were elevated in the F2 offspring of OXT-treated F1 dams, but IFNγ was not correlated with the behavioral effects. These results support the hypothesis that maternal AVP and OXT treatment have context- and behavior-specific effects on peripheral IFNγ levels and perseverative, anxiety, and social behaviors in the female offspring of early-life social stress-exposed dams. Both maternal AVP and OXT are effective at preventing social stress-induced increases in self-directed measures of anxiety, and AVP is particularly effective at preventing impairments in overall social contact. OXT is specifically effective at preventing repetitive/perseverative behaviors, yet is ineffective at preventing deficits in overall social behavior.en
dc.description.versionPublished versionen
dc.format.extent11 page(s)en
dc.format.mediumElectronic-eCollectionen
dc.format.mimetypeapplication/pdfen
dc.identifierARTN 155 (Article number)en
dc.identifier.doihttps://doi.org/10.3389/fendo.2016.00155en
dc.identifier.eissn1664-2392en
dc.identifier.issn1664-2392en
dc.identifier.orcidElnady, Fawzy [0000-0003-4282-7949]en
dc.identifier.pmid28018290 (pubmed)en
dc.identifier.urihttp://hdl.handle.net/10919/100049en
dc.identifier.volume7en
dc.language.isoenen
dc.publisherFrontiersen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectScience & Technologyen
dc.subjectLife Sciences & Biomedicineen
dc.subjectEndocrinology & Metabolismen
dc.subjectsocial stressen
dc.subjectdepressionen
dc.subjectdepression and anxiety disordersen
dc.subjectinterferon-gammaen
dc.subjectoxytocinen
dc.subjectvasopressinen
dc.subjectsocial behavioren
dc.subjectinflammationen
dc.subjectV1A RECEPTOR ANTAGONISTen
dc.subjectARGININE-VASOPRESSINen
dc.subjectGENE-EXPRESSIONen
dc.subjectCAREen
dc.subjectRATSen
dc.subjectDEPRESSIONen
dc.subjectAGGRESSIONen
dc.subjectPROLACTINen
dc.subjectANXIETYen
dc.subjectCORTICOSTERONEen
dc.subject1103 Clinical Sciencesen
dc.subject1111 Nutrition and Dieteticsen
dc.titleEffects of Chronic Social Stress and Maternal Intranasal Oxytocin and Vasopressin on Offspring Interferon-gamma and Behavioren
dc.title.serialFrontiers in Endocrinologyen
dc.typeArticleen
dc.type.dcmitypeTexten
dc.type.otherArticleen
dc.type.otherJournalen
dcterms.dateAccepted2016-11-28en
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Biomedical Sciences and Pathobiologyen
pubs.organisational-group/Virginia Techen

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