Frame-Based Stereotactic Biopsy of Canine Brain Masses: Technique and Clinical Results in 26 Cases

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dc.contributor.authorRossmeisl, John H. Jr.en
dc.contributor.authorAndriani, Rudy T.en
dc.contributor.authorCecere, Thomas E.en
dc.contributor.authorLahmers, Kevin K.en
dc.contributor.authorLeRoith, Tanyaen
dc.contributor.authorZimmerman, Kurt L.en
dc.contributor.authorGibo, Denise M.en
dc.contributor.authorDebinski, Waldemaren
dc.contributor.departmentBiomedical Sciences and Pathobiologyen
dc.contributor.departmentSmall Animal Clinical Sciencesen
dc.contributor.departmentSchool of Biomedical Engineering and Sciencesen
dc.date.accessioned2016-11-16T01:51:07Zen
dc.date.available2016-11-16T01:51:07Zen
dc.date.issued2015en
dc.description.abstractThis report describes the methodology, diagnostic yield, and adverse events (AE) associated with frame-based stereotactic brain biopsies (FBSB) obtained from 26 dogs with solitary forebrain lesions. Medical records were reviewed from dogs that underwent FBSB using two stereotactic headframes designed for use in small animals and compatible with computed tomographic (CT) and magnetic resonance (MR) imaging. Stereotactic plans were generated from MR and CT images using commercial software, and FBSB performed both with (14/26) and without intraoperative image guidance. Records were reviewed for diagnostic yield, defined as the proportion of biopsies producing a specific neuropathological diagnosis, AE associated with FBSB, and risk factors for the development of AE. Postprocedural AE were evaluated in 19/26 dogs that did not proceed to a therapeutic intervention immediately following biopsy. Biopsy targets included intra-axial telencephalic masses (24/26), one intra-axial diencephalic mass, and one extra-axial parasellar mass. The median target volume was 1.99 cm(3). No differences in patient, lesion, or outcome variables were observed between the two headframe systems used or between FBSB performed with or without intraoperative CT guidance. The diagnostic yield of FBSB was 94.6%. Needle placement error was a significant risk factor associated with procurement of non-diagnostic biopsy specimens. Gliomas were diagnosed in 24/26 dogs, and meningioma and granulomatous meningoencephalitis in 1 dog each. AE directly related to FBSB were observed in a total of 7/26 (27%) of dogs. Biopsy-associated clinical morbidity, manifesting as seizures and transient neurological deterioration, occurred in 3/19 (16%) of dogs. The case fatality rate was 5.2% (1/19 dogs), with death attributable to intracranial hemorrhage. FBSB using the described apparatus was relatively safe and effective at providing neuropathological diagnoses in dogs with focal forebrain lesions.en
dc.description.versionPublished versionen
dc.format.extent20 - ? page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fvets.2015.00020en
dc.identifier.urihttp://hdl.handle.net/10919/73466en
dc.identifier.volume2en
dc.language.isoenen
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pubmed/26664949en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectbrain tumoren
dc.subjectdogen
dc.subjectgliomaen
dc.subjectneurooncologyen
dc.subjectneurosurgeryen
dc.titleFrame-Based Stereotactic Biopsy of Canine Brain Masses: Technique and Clinical Results in 26 Casesen
dc.title.serialFrontiers in Veterinary Scienceen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Biomedical Sciences and Pathobiologyen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/CVM T&R Facultyen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Small Animal Clinical Sciencesen

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