Impedance Measurement of Cells; Experiment and Analysis of Passivation Layer

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dc.contributor.authorSreedharan Nair, Shree Narayananen
dc.contributor.committeechairAgah, Masouden
dc.contributor.committeememberMeehan, Kathleenen
dc.contributor.committeememberDavalos, Rafael V.en
dc.contributor.departmentElectrical and Computer Engineeringen
dc.date.accessioned2014-03-14T21:52:34Zen
dc.date.adate2010-01-22en
dc.date.available2014-03-14T21:52:34Zen
dc.date.issued2009-11-20en
dc.date.rdate2010-01-22en
dc.date.sdate2009-12-24en
dc.description.abstractBiological cells like any other material do conduct electricity. Though they come across as insulators, the resistance to the flow of current, i.e. impedance, could be used to characterize the cell itself. In this aspect, the impedance of cells can be a promising tool to investigate the state of the cell. A simple way of measuring the impedance would be a planar-microelectrode method. The cells are contained in culture medium while measurements are taken with micro-electrodes fabricated on top of a substrate. Since both the probe "tips" do not come in contact with the probed object, the impedance to be measured includes some components apart from that contributed by the cells. There have been publications reporting the usage of impedance of a cell to determine changes in the state of cells due to healing, drug candidate testing, functional genomic studies and so on. In this thesis, an effort has been made to measure the impedance of cells. Further, a component of the sensor, the passivation layer has been investigated for its contribution to the measured impedance in a quantitative manner.en
dc.description.degreeMaster of Scienceen
dc.identifier.otheretd-12242009-232636en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-12242009-232636/en
dc.identifier.urihttp://hdl.handle.net/10919/46424en
dc.publisherVirginia Techen
dc.relation.haspartSreedharanNair_SN_T_2009.pdfen
dc.relation.haspartVTFairUse_Combined.pdfen
dc.relation.haspartFig3_1.pdfen
dc.relation.haspartFig2_2.pdfen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectbio-impedanceen
dc.subjectModelingen
dc.subjectanalysisen
dc.titleImpedance Measurement of Cells; Experiment and Analysis of Passivation Layeren
dc.typeThesisen
thesis.degree.disciplineElectrical and Computer Engineeringen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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