Vascular Endothelial Growth Factor in the Aqueous Humor of Dogs With and Without Intraocular Disease

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dc.contributor.authorSandberg, Christina Annen
dc.contributor.committeechairHerring, Ian P.en
dc.contributor.committeememberLeRoith, Tanyaen
dc.contributor.committeememberHuckle, William R.en
dc.contributor.committeememberRossmeisl, John H. Jr.en
dc.contributor.committeememberPickett, J. Phillipen
dc.contributor.departmentBiomedical and Veterinary Sciencesen
dc.date.accessioned2014-03-14T21:38:52Zen
dc.date.adate2009-07-14en
dc.date.available2014-03-14T21:38:52Zen
dc.date.issued2009-06-08en
dc.date.rdate2009-07-14en
dc.date.sdate2009-06-19en
dc.description.abstractVascular endothelial growth factor A (VEGF) is a potent mediator of blood vessel formation throughout the body. Intraocular diseases characterized by inflammation, hypoxia or neoplasia induce new blood vessel formation within the eye. The end result of such blood vessel formation may be blinding sequellae such as glaucoma from outflow obstruction or hyphema from intraocular hemorrhage. Elevated VEGF concentrations in the aqueous humor and vitreous are documented in a number of human intraocular disease processes, including tumors, retinal detachment and uveitic glaucoma. Pharmacotherapy inhibiting VEGF expression demonstrates promise for control of some of these ophthalmic conditions. We quantified and compared VEGF concentrations in canine aqueous humor samples from 13 dogs with normal eyes and 226 eyes from 178 dogs with a variety of ophthalmic diseases by ELISA. Dogs with primary cataract, diabetic cataract, primary glaucoma, uveitic glaucoma, aphakic/pseudophakic glaucoma, retinal detachment, lens luxation and neoplasia were evaluated. Elevated VEGF concentrations were found in all disease conditions tested as compared to normal dogs excepting cataracts and diabetic cataracts. Elevated aqueous humor VEGF concentrations were found in dogs with pre-iridal fibrovascular membranes (PIFM) as compared to dogs without PIFM. These results are consistent with the hypothesis that VEGF has a role in the causation or progression of a variety of canine ocular disorders.en
dc.description.degreeMaster of Scienceen
dc.identifier.otheretd-06192009-130900en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-06192009-130900/en
dc.identifier.urihttp://hdl.handle.net/10919/43367en
dc.publisherVirginia Techen
dc.relation.haspartCASandberg_MS_2009.pdfen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectcanineen
dc.subjectglaucomaen
dc.subjectpre-iridal fibrovascular membraneen
dc.subjectVEGFen
dc.titleVascular Endothelial Growth Factor in the Aqueous Humor of Dogs With and Without Intraocular Diseaseen
dc.typeThesisen
thesis.degree.disciplineBiomedical and Veterinary Sciencesen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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