Evaluation of clinical methods of pulmonary gas exchange assessment in the standing horse

dc.contributor.authorDavis, Michael S.en
dc.contributor.committeechairMurray, Michael J.en
dc.contributor.committeememberDonaldson, Lydia L.en
dc.contributor.committeememberFurr, Martin O.en
dc.contributor.departmentVeterinary Scienceen
dc.date.accessioned2014-03-14T21:27:41Zen
dc.date.adate2009-01-24en
dc.date.available2014-03-14T21:27:41Zen
dc.date.issued1995-07-05en
dc.date.rdate2009-01-24en
dc.date.sdate2009-01-24en
dc.description.abstractThere are limited methods of assessing pulmonary function in horses at rest. In this study, we developed clinical techniques to measure gas exchange efficiency in horses. These techniques were then used to evaluate horses with varying degrees of lower respiratory disease. Three groups of horses (Group 1: asymptomatic, n=6; Group 2: symptomatic only with rebreathing, n=11; Group 3: symptomatic at rest, n=9) were selected based on physical exam, transtracheal aspirate, and thoracic radiographs. Blood samples were obtained from the transverse facial artery and jugular vein. Maximal end-tidal CO₂ tension (E<sub>T</sub>CO₂) was measured by an infrared capnograph through a facemask. Alveolar O, tension, alveolar dead space fraction (V<sub>DB</sub>/V<sub>T</sub>), and physiologic shunt fraction (Q<sub>S</sub>/Q<sub>T</sub>) were calculated using standard formulas. Horses with both mild and severe signs of lower respiratory disease had significant (p<0.05) differences in gas exchange indices at rest compared to asymptomatic horses. Albuterol was administered to seven of the Group 2 horses from a metered-dose inhaler through an equine facemask at a dose of 90 μg per 100 kg. Blood samples and tidal gas samples were obtained 15 minutes post-treatment, and Q<sub>S</sub>/Q<sub>T</sub> and (V<sub>DB</sub>/V<sub>T</sub>) were calculated. Albuterol caused significant (p<0.05) hypoxemia 15 minutes following inhaled administration. This was accompanied by a significant increase in Q<sub>S</sub>/Q<sub>T</sub>, suggesting that the hypoxemia was due to increases in which the ratios of ventilation to perfusion were decreased.en
dc.description.degreeMaster of Scienceen
dc.format.extentvii, 93 leavesen
dc.format.mediumBTDen
dc.format.mimetypeapplication/pdfen
dc.identifier.otheretd-01242009-063110en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-01242009-063110/en
dc.identifier.urihttp://hdl.handle.net/10919/40732en
dc.language.isoenen
dc.publisherVirginia Techen
dc.relation.haspartLD5655.V855_1995.D385.pdfen
dc.relation.isformatofOCLC# 34289815en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectalveolar dead space fractionen
dc.subjectphysiologic shunt fractionen
dc.subjectrespiratoryen
dc.subject.lccLD5655.V855 1995.D385en
dc.titleEvaluation of clinical methods of pulmonary gas exchange assessment in the standing horseen
dc.typeThesisen
dc.type.dcmitypeTexten
thesis.degree.disciplineVeterinary Scienceen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen
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