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Baicalein Protects against Type 2 Diabetes via Promoting Islet β-Cell Function in Obese Diabetic Mice

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dc.contributor.authorFu, Y.en
dc.contributor.authorLuo, J.en
dc.contributor.authorJia, Z.en
dc.contributor.authorZhen, W.en
dc.contributor.authorZhou, K.en
dc.contributor.authorGilbert, Elizabeth R.en
dc.contributor.authorLiu, D.en
dc.contributor.authorLee, H.en
dc.contributor.departmentHuman Nutrition, Foods, and Exerciseen
dc.date.accessioned2017-01-07T23:10:08Zen
dc.date.available2017-01-07T23:10:08Zen
dc.date.issued2014en
dc.description.abstractIn both type 1 (T1D) and type 2 diabetes (T2D), the deterioration of glycemic control over time is primarily caused by an inadequate mass and progressive dysfunction of β-cell, leading to the impaired insulin secretion. Here, we show that dietary supplementation of baicalein, a flavone isolated from the roots of Chinese herb Scutellaria baicalensis, improved glucose tolerance and enhanced glucose-stimulated insulin secretion (GSIS) in high-fat diet (HFD-) induced middle-aged obese mice. Baicalein had no effect on food intake, body weight gain, circulating lipid profile, and insulin sensitivity in obese mice. Using another mouse model of type 2 diabetes generated by high-fat diet (HFD) feeding and low doses of streptozotocin injection, we found that baicalein treatment significantly improved hyperglycemia, glucose tolerance, and blood insulin levels in these middle-aged obese diabetic mice, which are associated with the improved islet β-cell survival and mass. In the in vitro studies, baicalein significantly augmented GSIS and promoted viability of insulin-secreting cells and human islets cultured either in the basal medium or under chronic hyperlipidemic condition. These results demonstrate that baicalein may be a naturally occurring antidiabetic agent by directly modulating pancreatic β-cell function.en
dc.description.versionPublished versionen
dc.format.extent846742 - 13 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationYu Fu, Jing Luo, Zhenquan Jia, Wei Zhen, Kequan Zhou, Elizabeth Gilbert, Dongmin Liu, "Baicalein Protects against Type 2 Diabetes via Promoting Islet β-Cell Function in Obese Diabetic Mice", International Journal of Endocrinology, vol. 2014, Article ID 846742, 13 pages, 2014. https://doi.org/10.1155/2014/846742en
dc.identifier.doihttps://doi.org/10.1155/2014/846742en
dc.identifier.issn1687-8337en
dc.identifier.urihttp://hdl.handle.net/10919/74008en
dc.identifier.volume2014en
dc.language.isoenen
dc.publisherHindawien
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pubmed/25147566en
dc.rightsCreative Commons Attribution 3.0 Unporteden
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/en
dc.titleBaicalein Protects against Type 2 Diabetes via Promoting Islet β-Cell Function in Obese Diabetic Miceen
dc.title.serialInternational Journal of Endocrinologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciencesen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/CALS T&R Facultyen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Food Science and Technologyen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Human Nutrition, Foods, & Exerciseen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen

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