Interleukin Receptor Associated Kinase 1 Signaling and Its Association with Cardiovascular Diseases

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dc.contributor.authorZheng, Youjingen
dc.contributor.authorHe, Jia-Qiangen
dc.date.accessioned2022-07-14T13:09:09Zen
dc.date.available2022-07-14T13:09:09Zen
dc.date.issued2022-03-09en
dc.description.abstractToll-like receptors (TLRs) and interleukin-1 receptor (IL-1R) directly interact with intracellular interleukin receptor associated kinase (IRAK) family members to initialize innate immune and inflammatory responses following activation by pathogen-associated or hostderived elements. Although four IRAK family members [IRAK1, 2, 3 (i.e., IRAK-M), and 4] are involved in TLR and IL-1R signaling pathways, IL-1R > IRAK1 signaling appears to be the most studied pathway, with sufficient evidence to support its central role linking the innate immune response to the pathogenesis of various diseases, including cancers, metabolic disorders, and non-infectious immune disorders. However, IRAK1's involvement in cardiovascular diseases was only recently revealed and the detailed mechanism underling the pathogenesis of cardiovascular diseases, such as atherosclerosis, myocardial infarction, and heart failure (all non-infectious disorders), remains largely unknown with very limited publications to date. This review aims to summarize the overall roles of the IRAK family, especially IRAK1, in mediating the development of cardiovascular diseases.en
dc.description.notesThis work was supported by the NIH grant (1R15HL140528-01 for JQH) , One-Health seed grant (PJ6SPVHJ for JQH) by the College of Veterinary Medicine at Virginia Tech and the Edward Via College of Osteopathic Medicine, Interdisciplinary Graduate Education Program of Regenerative Medicine (IGEP-RM for YJZ) , and Internal Research Competition (IRC) Seed Grant (#178391 for JQH) by the College of Veterinary Medicine at Virginia Tech. The funders had no role in the study design, data collection and analysis, decision to publish, and preparation of the manuscript.en
dc.description.sponsorshipNIH [1R15HL140528-01]; College of Veterinary Medicine at Virginia Tech; Edward Via College of Osteopathic Medicine, Interdisciplinary Graduate Education Program of Regenerative Medicine; Internal Research Competition (IRC) [178391]en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.31083/j.rcm2303097en
dc.identifier.eissn2153-8174en
dc.identifier.issn1530-6550en
dc.identifier.issue3en
dc.identifier.other97en
dc.identifier.pmid35345264en
dc.identifier.urihttp://hdl.handle.net/10919/111241en
dc.identifier.volume23en
dc.language.isoenen
dc.publisherIMR Pressen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectinterleukin-1 receptor associated kinase 1en
dc.subjectinnate immune responseen
dc.subjectsignaling pathwaysen
dc.subjecttoll-like receptoren
dc.subjectinterleukin-1 receptoren
dc.subjectendothelial cellsen
dc.subjectvascular smooth muscle cellsen
dc.subjectcardiomyocytesen
dc.subjectatherosclerosisen
dc.subjectmyocardial infarctionen
dc.subjectheart failureen
dc.titleInterleukin Receptor Associated Kinase 1 Signaling and Its Association with Cardiovascular Diseasesen
dc.title.serialReviews in Cardiovascular Medicineen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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