The Design of Polyelectrolyte Multilayers Using Galactosylated Chitosan

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dc.contributor.authorArca, Hale Cigdemen
dc.contributor.committeechairRajagopalan, Padmavathyen
dc.contributor.committeememberDavis, Richey M.en
dc.contributor.committeememberEdgar, Kevin J.en
dc.contributor.departmentMacromolecular Science and Engineeringen
dc.date.accessioned2014-03-14T21:35:53Zen
dc.date.adate2012-06-15en
dc.date.available2014-03-14T21:35:53Zen
dc.date.issued2012-04-26en
dc.date.rdate2012-06-15en
dc.date.sdate2012-05-09en
dc.description.abstractA major challenge in hepatic tissue engineering is that liver cells rapidly lose their phenotype in in vitro cell culture systems. For this reason, it is necessary to design biomaterials that can support and enhance hepatic functions. Hepatocytes have a surface protein, called the asialoglycoprotein receptor (ASGP-R), which interacts with galactose via a specific receptor-ligand interaction. Polyelectrolyte multilayers (PEMs) were prepared by the layer by layer method, which is based on electrostatic attractions between oppositely charged polyelectrolytes (PEs). Anionic (hyaluronic acid) and cationic (chitosan and galactosylated chitosan) PEs were used in the fabrication of detachable, free-standing PEMs. The main focus of this study is the design of PEMs comprised of 50 bilayers of PEs. PEMs that contained galactose functional groups were assembled with either 5 or 10 bilayers of galactosylated chitosan (5 - 10 % of galactosylation). Optical properties, solvent stability and surface topography of the PEMs were measured.en
dc.description.degreeMaster of Scienceen
dc.identifier.otheretd-05092012-004123en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-05092012-004123/en
dc.identifier.urihttp://hdl.handle.net/10919/42578en
dc.publisherVirginia Techen
dc.relation.haspartArca_HC_T_2012_3.pdfen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectASGP-Ren
dc.subjectChitosanen
dc.subjectGalactoseen
dc.subjectLiver modelsen
dc.subjectPolyelectrolyte multilayersen
dc.titleThe Design of Polyelectrolyte Multilayers Using Galactosylated Chitosanen
dc.typeThesisen
thesis.degree.disciplineMacromolecular Science and Engineeringen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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