Case Report: Disorder of Sexual Development in a Chinese Crested Dog With XX/XY Leukocyte Chimerism and Mixed Cell Testicular Tumors

Simple item page
dc.contributor.authorSchwartz, Rebeccaen
dc.contributor.authorSugai, Nicole J.en
dc.contributor.authorEden, Kristinen
dc.contributor.authorCastaneda, Caitlinen
dc.contributor.authorJevit, Matthewen
dc.contributor.authorRaudsepp, Terjeen
dc.contributor.authorCecere, Julie T.en
dc.date.accessioned2022-09-20T16:31:06Zen
dc.date.available2022-09-20T16:31:06Zen
dc.date.issued2022-07-08en
dc.date.updated2022-09-20T15:50:25Zen
dc.description.abstractA 10-year-old intact female Chinese Crested dog was presented for evaluation and further diagnostics due to persistent symptoms of vulvar swelling, vaginal discharge, and an 8-year history of acyclicity. At presentation, generalized hyperpigmentation and truncal alopecia were identified, with no aberrations of the female phenotype. Vaginal cytology confirmed the influence of estrogen at multiple veterinary visits, and hormonal screening of progesterone and anti-Mullerian hormone indicated gonadal presence. Based on findings from abdominal laparotomy and gonadectomy, the tissue was submitted for histopathology. Histopathologic evaluation identified the gonads to be abnormal testes containing multiple Sertoli and interstitial (Leydig) cell tumors. The histopathologic diagnosis of testes and concurrent normal external female phenotype in the patient lead to a diagnosis of a disorder of sexual development (DSD). Karyotype evaluation by conventional and molecular analysis revealed a two cell line chimeric pattern of 78,XX (80%) and 78,XY (20%) among blood leukocytes, as well as a positive PCR test for the Y-linked SRY gene. Cytogenetic analysis of skin fibroblasts revealed the presence of 78,XX cells exclusively, and PCR tests for the Y-linked SRY gene were negative in the hair and skin samples. These results are consistent with an XX/XY blood chimerism. This is one of the few case reports of a canine with the diagnosis of leukocyte chimerism with normal female phenotypic external genitalia. This case illustrates a distinct presentation for hormonally active Sertoli cell tumorigenesis and demonstrates surgery as a curative treatment option for clinically affected patients.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fvets.2022.937991en
dc.identifier.eissn2297-1769en
dc.identifier.issn2297-1769en
dc.identifier.otherPMC9309221en
dc.identifier.pmid35898552en
dc.identifier.urihttp://hdl.handle.net/10919/111931en
dc.identifier.volume9en
dc.language.isoenen
dc.publisherFrontiersen
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/35898552en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectLeydig cell tumoren
dc.subjectSertoli cell tumoren
dc.subjectcanineen
dc.subjectchimerismen
dc.subjectdisorder of sexual development (DSD)en
dc.subjectContraception/Reproductionen
dc.titleCase Report: Disorder of Sexual Development in a Chinese Crested Dog With XX/XY Leukocyte Chimerism and Mixed Cell Testicular Tumorsen
dc.title.serialFrontiers in Veterinary Scienceen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherJournal Articleen
dcterms.dateAccepted2022-06-16en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicineen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/VTC Basic Sciences Educationen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/VTC Basic Sciences Education/VTC Basic Sciences Educationen

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Case Report Disorder of Sexual Development in a Chinese Crested Dog With XXXY Leukocyte Chimerism and Mixed Cell Testicular .pdf
Size:
1.31 MB
Format:
Adobe Portable Document Format
Description:
Published version
Download

Collections

All Faculty Deposits
Open Access Subvention Fund Articles
Scholarly Works, Small Animal Clinical Sciences
Scholarly Works, Virginia Tech Carilion School of Medicine (VTCSOM)