Effects of opioid antagonism on thermoregulation during prolonged exercise in the heat

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dc.contributor.authorHickey, Matthew Seanen
dc.contributor.committeechairHerbert, William G.en
dc.contributor.committeememberRankin, Janet L. Walbergen
dc.contributor.committeememberLee, John C.en
dc.contributor.departmentHealth and Physical Educationen
dc.date.accessioned2014-03-14T21:37:50Zen
dc.date.adate2009-06-11en
dc.date.available2014-03-14T21:37:50Zen
dc.date.issued1990-08-05en
dc.date.rdate2009-06-11en
dc.date.sdate2009-06-11en
dc.description.abstractFive adult male volunteers were studied to investigate the effect of opiate receptor blockade on the physiological response to a maximum of 60 minutes of stationary cycling at 70% V02peak in a hot (33 0 C/65% RH) environment. Exercise bouts were conducted following the administration of naloxone (4mg IV) 5 minutes prior to exercise with a follow-up 4mg dose at 25 minutes of exercise. In the placebo trial, volume-matched doses of saline were administered at the same points. No significant drug effect was observed on rectal or mean skin temperature during exercise. Post-exercise skin temperature was significantly (P<.001) higher on naloxone versus saline. Forearm blood flow (FBF) was consistently higher from minute 25 of exercise until test termination, although only the minute 25 and minute 55 data points were significantly elevated (P<.05, P<.005, respectively) . The rectal temperature threshold at which FBF plateaued was higher on naloxone (P=.054), and the FBF: rectal temperature slope was higher on naloxone throughout the trial. No significant changes were observed in heart rate or estimated mean arterial pressures, although both were consistently lower on naloxone. Gross sweat response was not altered by the drug. Plasma Beta-Endorphin was significantly (P<.Ol) higher on naloxone versus saline, and Beta-Endorphin was significantly elevated in the naloxone trial only. The observation that FBF was significantly higher on naloxone without inducing compensatory heart rate or blood pressure changes suggests that the opioids may be involved in the blood volume shifts that occur during prolonged exercise in the heat.en
dc.description.degreeMaster of Scienceen
dc.format.extentix, 184 leavesen
dc.format.mediumBTDen
dc.format.mimetypeapplication/pdfen
dc.identifier.otheretd-06112009-063109en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-06112009-063109/en
dc.identifier.urihttp://hdl.handle.net/10919/43122en
dc.language.isoenen
dc.publisherVirginia Techen
dc.relation.haspartLD5655.V855_1990.H439.pdfen
dc.relation.isformatofOCLC# 23965326en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subject.lccLD5655.V855 1990.H439en
dc.subject.lcshBlood flowen
dc.subject.lcshBody temperature -- Regulationen
dc.subject.lcshEndorphins -- Receptorsen
dc.subject.lcshExercise -- Physiological aspectsen
dc.subject.lcshNaloxoneen
dc.titleEffects of opioid antagonism on thermoregulation during prolonged exercise in the heaten
dc.typeThesisen
dc.type.dcmitypeTexten
thesis.degree.disciplineHealth and Physical Educationen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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