Daily Rice Bran Consumption for Six Months Influences Serum Glucagon-Like Peptide-2 And Metabolite Profiles Without Differences in Trace Elements and Heavy Metals in Weaning Nicaraguan Infants At 12 Months of Age

Simple item page
dc.contributor.authorZambrana, Luis E.en
dc.contributor.authorWeber, Annikaen
dc.contributor.authorBorresen, Erica C.en
dc.contributor.authorZarei, Imanen
dc.contributor.authorPerez, Johannen
dc.contributor.authorPerez, Claudia E.en
dc.contributor.authorRodríguez, Ikeren
dc.contributor.authorBecker-Dreps, Sylviaen
dc.contributor.authorYuan, Lijuanen
dc.contributor.authorVilchez, Samuelen
dc.contributor.authorRyan, Elizabeth P.en
dc.date.accessioned2021-12-30T17:47:22Zen
dc.date.available2021-12-30T17:47:22Zen
dc.date.issued2021-09-01en
dc.date.updated2021-12-30T17:47:19Zen
dc.description.abstractBackground: Environmental enteric dysfunction (EED) is associated with chronic gut inflammation affecting nutrient absorption and development of children, primarily in low- and middle-income countries. Several studies have shown that rice bran (RB) supplementation provides nutrients and modulates gut inflammation, which may reduce risk for undernutrition. Objective: The aim was to evaluate the effect of daily RB dietary supplementation for 6 mo on serum biomarkers in weaning infants and associated changes in serum and stool metabolites. Methods: A 6-mo randomized-controlled dietary intervention was conducted in a cohort of weaning 6-mo-old infants in León, Nicaragua. Anthropometric indices were obtained at 6, 8, and 12 mo. Serum and stool ionomics and metabolomics were completed at the end of the 6-mo intervention using inductively coupled plasma MS and ultra-high performance LC-tandem MS. The α1-acid glycoprotein, C-reactive protein, and glucagon-like peptide 2 (GLP-2) serum EED biomarkers were measured by ELISA. Results: Twenty-four infants in the control group and 23 in the RB group successfully completed the 6-mo dietary intervention with 90% dietary compliance. RB participants had higher concentrations of GLP-2 as compared with control participants at 12 mo [median (IQR): 743.53 (380.54) pg/mL vs. 592.50 (223.59) pg/mL; P = 0.04]. Metabolite profiles showed significant fold differences of 39 serum metabolites and 44 stool metabolites from infants consuming RB compared with control, and with significant metabolic pathway enrichment scores of 4.7 for the tryptophan metabolic pathway, 5.7 for polyamine metabolism, and 5.7 for the fatty acid/acylcholine metabolic pathway in the RB group. No differences were detected in serum and stool trace elements or heavy metals following daily RB intake for 6 mo. Conclusions: RB consumption influences a suite of metabolites associated with growth promotion and development, while also supporting nutrient absorption as measured by changes in serum GLP-2 in Nicaraguan infants. This clinical trial was registered at https://clinicaltrials.gov as NCT02615886.en
dc.description.versionPublished versionen
dc.format.extentPages nzab101en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1093/cdn/nzab101en
dc.identifier.eissn2475-2991en
dc.identifier.issn2475-2991en
dc.identifier.issue9en
dc.identifier.orcidYuan, Lijuan [0000-0003-0709-5228]en
dc.identifier.otherPMC8421236en
dc.identifier.othernzab101 (PII)en
dc.identifier.pmid34514286en
dc.identifier.urihttp://hdl.handle.net/10919/107294en
dc.identifier.volumenzab101en
dc.language.isoenen
dc.publisherOxford University Pressen
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/34514286en
dc.rightsCreative Commons Attribution-NonCommercial 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectenvironmental enteric dysfunction biomarkersen
dc.subjectglucagon-like peptide 2en
dc.subjectheavy metalsen
dc.subjectmetabolomeen
dc.subjectrice branen
dc.subjecttrace elementsen
dc.subjectundernutritionen
dc.titleDaily Rice Bran Consumption for Six Months Influences Serum Glucagon-Like Peptide-2 And Metabolite Profiles Without Differences in Trace Elements and Heavy Metals in Weaning Nicaraguan Infants At 12 Months of Ageen
dc.title.serialCurrent Developments in Nutritionen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherArticleen
dcterms.dateAccepted2021-07-16en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Biomedical Sciences and Pathobiologyen
pubs.organisational-group/Virginia Tech/University Research Institutesen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciencesen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/CVM T&R Facultyen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciences/Durelle Scotten

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Daily Rice Bran Consumption for 6 Months Influences Serum Glucagon-Like Peptide 2 and Metabolite Profiles without Difference.pdf
Size:
1.44 MB
Format:
Adobe Portable Document Format
Description:
Published version
Download

Collections

All Faculty Deposits
Scholarly Works, Biomedical Sciences and Pathobiology