Does Insomnia Increase the Risk of Suicide in Hospitalized Patients with Major Depressive Disorder? A Nationwide Inpatient Analysis from 2006 to 2015
| dc.contributor.author | Mansuri, Zeeshan | en |
| dc.contributor.author | Reddy, Abhishek | en |
| dc.contributor.author | Vadukapuram, Ramu | en |
| dc.contributor.author | Thootkur, Mounica | en |
| dc.contributor.author | Trivedi, Chintan | en |
| dc.date.accessioned | 2022-04-22T12:28:30Z | en |
| dc.date.available | 2022-04-22T12:28:30Z | en |
| dc.date.issued | 2022-04-19 | en |
| dc.date.updated | 2022-04-21T21:03:38Z | en |
| dc.description.abstract | <b>Introduction.</b> Insomnia is an important symptom associated with major depressive disorder (MDD). In addition, it is one of the risk factors for suicide. Studies have shown the relationship be-tween insomnia and suicidal behavior in patients with MDD. However, this association has not been evaluated in a large sample of hospitalized patients. <b>Objectives.</b> To evaluate the suicidal be-havior in MDD patients with insomnia compared to those without insomnia. <b>Methods.</b> From the National Inpatient Sample (NIS 2006–2015) database using the ICD-9 code, patients’ data were obtained with the primary diagnosis of MDD and comorbid diagnosis of insomnia disorders (MDD+I). These patients were compared with MDD patients without insomnia disorders (MDD–I) by performing a 1:2 match for the primary diagnosis code. Suicidal ideation/attempt da-ta were compared between the groups by multivariate logistic regression analysis. <b>Results.</b> After the diagnostic code matching, 139061 patients were included in the MDD+I group and 276496 patients in the MDD–I group. MDD+I patients were older (47 years vs. 45 years, <i>p</i> < 0.001) com-pared to the MDD–I group. The rate of suicidal ideation/attempt was 56.0% in the MDD+I group and 42.0% in the MDD–I group (<i>p</i> < 0.001). After adjusting for age, sex, race, borderline personal-ity disorders, anxiety disorders, and substance use disorders, ‘insomnia’ was associated with 1.71 times higher odds of suicidal behavior among MDD patients admitted to the hospital. (Odds ratio: 1.71, 95% confidence interval 1.60–1.82, <i>p</i> < 0.001). Conclusions. Insomnia among MDD patients is significantly associated with the risk of suicide. MDD patients with insomnia need to be closely monitored for suicidal behavior. | en |
| dc.description.version | Published version | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.citation | Mansuri, Z.; Reddy, A.; Vadukapuram, R.; Thootkur, M.; Trivedi, C. Does Insomnia Increase the Risk of Suicide in Hospitalized Patients with Major Depressive Disorder? A Nationwide Inpatient Analysis from 2006 to 2015. Behav. Sci. 2022, 12, 117. | en |
| dc.identifier.doi | https://doi.org/10.3390/bs12050117 | en |
| dc.identifier.uri | http://hdl.handle.net/10919/109729 | en |
| dc.language.iso | en | en |
| dc.publisher | MDPI | en |
| dc.rights | Creative Commons Attribution 4.0 International | en |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en |
| dc.subject | insomnia | en |
| dc.subject | depression | en |
| dc.subject | suicide | en |
| dc.title | Does Insomnia Increase the Risk of Suicide in Hospitalized Patients with Major Depressive Disorder? A Nationwide Inpatient Analysis from 2006 to 2015 | en |
| dc.title.serial | Behavioral Science | en |
| dc.type | Article - Refereed | en |
| dc.type.dcmitype | Text | en |