A Dual PET/MR Imaging Nanoprobe: 124I Labeled Gd3N@C80

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dc.contributor.authorLuo, Jianqiaoen
dc.contributor.authorWilson, John D.en
dc.contributor.authorZhang, Jianyuanen
dc.contributor.authorHirsch, Jerry I.en
dc.contributor.authorDorn, Harry C.en
dc.contributor.authorFatouros, Panos P.en
dc.contributor.authorShultz, Michael D.en
dc.contributor.departmentChemistryen
dc.date.accessed2014-01-06en
dc.date.accessioned2014-01-15T14:16:33Zen
dc.date.available2014-01-15T14:16:33Zen
dc.date.issued2012-05-10en
dc.description.abstractThe current report describes the development of a dual modality tomographic agent for both positron emission tomography and magnetic resonance imaging (PET/MRI). The dual-modality agent in this study was based on a 124I (PET) radiolabeled tri-gadolinium endohedral metallofullerene Gd3N@C80 (MRI) nanoprobe platform. The outer surface of the fullerene cage of the Gd3N@C80 metallofullerenes was surface functionalized with carboxyl and hydroxyl groups (f-Gd3N@C80) using previously developed procedures and subsequently iodinated with 124I to produce 124I-f-Gd3N@C80 nanoprobe. Orthotopic tumor-bearing rats were infused intratumorally by convection-enhanced delivery (CED) with the 124I-f-Gd3N@C80 agent and imaged by MRI or micro PET. The anatomical positioning and distribution of the 124I-f-Gd3N@C80 agent were comparable between the MRI and PET scans. The 124I-f-Gd3N@C80_ dual-agent distribution and infusion site within the tumor was clearly evident in both T1- and T2-weighted MR images. The results demonstrate the successful preparation of a dual-modality imaging agent, 124I-f-Gd3N@C80, which could ultimately be used for simultaneous PET/MR imaging.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationLuo, Jianqiao; Wilson, John D.; Zhang, Jianyuan; Hirsch, Jerry I.; Dorn, Harry C.; Fatouros, Panos P.; Shultz, Michael D. 2012. "A Dual PET/MR Imaging Nanoprobe: 124I Labeled Gd3N@C80." Appl. Sci. 2012, 2(2), 465-478; doi:10.3390/app2020465.en
dc.identifier.doihttps://doi.org/10.3390/app2020465en
dc.identifier.issn2076-3417en
dc.identifier.urihttp://hdl.handle.net/10919/24833en
dc.identifier.urlhttp://www.mdpi.com/2076-3417/2/2/465en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectPETen
dc.subjectMRIen
dc.subjectmetallofullereneen
dc.subjectiodinationen
dc.titleA Dual PET/MR Imaging Nanoprobe: 124I Labeled Gd3N@C80en
dc.title.serialApplied Sciencesen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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